Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Araceae

ABSTRACT: Evolutionary dynamics of mutational hotspots in subfamily Monsteriodeae (Araceae)

PROVIDER: PRJNA547622 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8655270.fastq.gz	Fastqsanger.gz
	SRR8655295.fastq.gz	Fastqsanger.gz
	SRR8655267.fastq.gz	Fastqsanger.gz
	SRR8655269.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Araceae

Project description:Chloroplast genomes of subfamily Pothoideae (Araceae)

| PRJNA547619 | ENA

Araceae, Aroideae

Project description:Evaluation of mutational dynamics of chloroplast genomes in Araceae

| PRJNA547613 | ENA

Project description:Evolutionary dynamics of chloroplast genomes in subfamily Aroideae (Araceae)

| PRJNA524889 | ENA

Genome-wide map of H3K4me3 and PRDM9-binding in 12 day post-partum mouse spermatocytes

Project description:PRDM9, a histone methyltransferase, initiates meiotic recombination by binding DNA at recombination hotspots and directing the position of DNA double-strand breaks (DSB). The DSB repair mechanism suggests that hotspots should eventually self-destruct, yet genome-wide recombination levels remain constant, a conundrum known as the hotspot paradox. To test if PRDM9 drives this evolutionary erosion, we compared activity of the Prdm9Cst allele in two Mus musculus subspecies, M.m. castaneus, in which Prdm9Cst arose, and M.m. domesticus, into which Prdm9Cst was introduced. Comparing these two strains, we find that haplotype differences at hotspots leads to qualitative and quantitative changes in PRDM9 binding and activity. Most variants affecting PRDM9Cst binding arose and were fixed in M.m castaneus, suppressing hotspot activity. Furthermore, M.m castaneus x M.m domesticus F1 hybrids exhibit novel hotspots, representing sites of historic evolutionary erosion. Together these data support a model where haplotype-specific PRDM9 binding directs biased gene conversion at hotspots, ultimately leading to hotspot erosion. Identify position of meiotic H3K4me3 from various sub-species of mice and F1 hybrids from crosses between subspecies. In addition, perform ChIP-seq analysis on the meiosis-specific methyltransferase PRDM9.

2015-01-13 | E-GEOD-60906 | biostudies-arrayexpress

Phylogeny and diversification history of the large Neotropical genus Philodendron (Araceae)

Project description:Phylogeny and diversification history of the genus Philodendron (Araceae)

| PRJEB25709 | ENA

Genome-wide map of H3K4me3 and PRDM9-binding in 12 day post-partum mouse spermatocytes

2015-01-13 | GSE60906 | GEO

Spo11-oligo mapping in Saccharomyces species (S. paradoxus, S. mikatae, S. kudriavzevii) and wild-derived S. cerevisiae strains (YPS128, UWOPS03-461.4)

Project description:The nonrandom distribution of meiotic recombination shapes heredity and genetic diversification. A widely held view is that individual hotspots - favored sites of recombination initiation - are always ephemeral because they evolve rapidly toward extinction. An alternative view, often ignored or dismissed as implausible, predicts conservation of the positions of hotspots if they are chromosomal features under selective constraint, such as gene promoters. Here we empirically test opposite predictions of these theories by comparing genome-wide maps of meiotic recombination initiation from widely divergent species in the Saccharomyces clade. We find that the frequent overlap of hotspots with promoters is true of the species tested and, consequently, hotspot positions are well conserved. Remarkably, however, the relative strength of individual hotspots is also highly conserved, as are larger-scale features of the distribution of recombination initiation. This stability, not predicted by prior models, suggests that the particular shape of the yeast recombination landscape is adaptive, and helps in understanding evolutionary dynamics of recombination in other species.

2015-08-17 | GSE71887 | GEO

Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders [Saturating mutagenesis]

Project description:Targeted protein degradation is a novel pharmacology established by drugs that recruit target proteins to E3 ubiquitin ligases. Based on the structure of the degrader and the target, different E3 interfaces are critically involved, thus forming defined "functional hotspots". Understanding disruptive mutations in functional hotspots informs on the architecture of the assembly, and highlights residues susceptible to acquire resistance phenotypes. Here, deep mutational scanning revealed hotspots that are conserved or specific for chemically distinct degraders and targets and validated hotspots mutated in patients that relapse from degrader treatment.

2022-09-09 | GSE198278 | GEO

Evolutionary Conservation and Functional Role of the SWI/SNF Complex Protein BDH in Arabidopsis: Insights into Catalytic Subcomplex Stability and Biological Implications [ChIP-Seq]

Project description:The SWI/SNF complexes play crucial roles in chromatin remodeling, with the protein BDH emerging as a key component in Arabidopsis. Through evolutionary analysis, we demonstrate the conservation of BDH function across mammals, yeast, and plants. Our study reveals that BDH is integral to the stability of the catalytic subcomplex within SWI/SNF assemblies. Furthermore, we elucidate the biological and molecular implications of BDH in Arabidopsis, highlighting its involvement in nucleosomal occupancy regulation. Mutational characterization and transcriptomic analyses underscore BDH's significance, shedding light on its multifaceted role in chromatin dynamics and gene regulation.

2024-10-10 | GSE268510 | GEO

Araceae

Project description:Thermoregulation in plants

| PRJDB5942 | ENA