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ATAC sequencing and RNA sequencing of L4-L6 mouse Dorsal Root Ganglia upon dorsal column axotomy plus injection of the histone deacetylase inhibitor MS275

ABSTRACT: ATAC sequencing and RNA sequencing of L4-L6 mouse Dorsal Root Ganglia upon dorsal column axotomy plus injection of the histone deacetylase inhibitor MS275

PROVIDER: PRJNA547783 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9216230_1.fastq.gz	Fastqsanger.gz
	SRR9216230_2.fastq.gz	Fastqsanger.gz
	SRR9216231_1.fastq.gz	Fastqsanger.gz
	SRR9216231_2.fastq.gz	Fastqsanger.gz
	SRR9216232_1.fastq.gz	Fastqsanger.gz

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ATAC sequencing and RNA sequencing of L4-L6 mouse Dorsal Root Ganglia upon dorsal column axotomy plus injection of the histone deacetylase inhibitor MS275

Project description:Purpose: compare the response of DRG neurons to a central axonal injury in presence of histone deacetylase inhibitor by measuring accessible chromatin and transcription Results: we found that MS-275 was able to induce changes in chromatin accessibility and gene expression. In particular, an increased accessibility correlated with changes in gene expression, and a decreased accessibility correlated with gene downregulation

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