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The RNA exosome nuclease complex regulates human embryonic stem cell differentiation [PAR-iCLIP]

ABSTRACT: The RNA exosome nuclease complex regulates human embryonic stem cell differentiation [PAR-iCLIP]

PROVIDER: PRJNA548148 | ENA |

REPOSITORIES: ENA

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The RNA exosome nuclease complex regulates human embryonic stem cell differentiation [PAR-iCLIP]

Project description:This work shows that the exosome modulates the levels of LINE-1 retrotransposons, miRNAs, lncRNAs and specific mRNAs that encode developmental regulators or affect their expression. The exosome restrains differentiation in part by degrading transcripts encoding FOXH1, a transcription factor crucial for mesendoderm formation.

2019-07-11 | GSE132466 | GEO

The RNA exosome nuclease complex regulates human embryonic stem cell differentiation

Project description:The RNA exosome nuclease complex regulates human embryonic stem cell differentiation

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iCLIP analysis of RNA substrates of the archaeal exosome (iCLIP)

Project description:In this study, an exoribonuclease was analyzed by iCLIP. The data documents the role of the archaeal exosome as an exoribonuclease and RNA-tailing enzyme interacting with all RNA classes. Mapping of most reads to mRNAs underlines the role of exosome in mRNA turnover, which is important for adaptation of prokaryotic cells to changing environmental conditions. The clustering of crosslink sites near 5’-ends of genes suggests simultaneous binding of both RNA ends by the S. solfataricus exosome. This may serve to prevent translation of mRNAs designated to degradation in 3’-5’ direction.

2020-11-24 | GSE149140 | GEO

iCLIP analysis of RNA substrates of the archaeal exosome (iCLIP)

Project description:iCLIP analysis of RNA substrates of the archaeal exosome (iCLIP)

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The RNA exosome nuclease complex regulates human embryonic stem cell differentiation [HITS-CLIP]

2019-07-11 | GSE132360 | GEO

The RNA exosome nuclease complex regulates human embryonic stem cell differentiation [HITS-CLIP]

Project description:The RNA exosome nuclease complex regulates human embryonic stem cell differentiation [HITS-CLIP]

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iCLIP analysis of RNA substrates of the archaeal exosome (RNA-Seq)

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The RNA exosome nuclease complex regulates human embryonic stem cell differentiation [RNA-Seq SS]