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Small intestinal inflammation shapes the transcriptomic signature of incoming monocytes in a partially Trem1-dependent mechanism

ABSTRACT: Small intestinal inflammation shapes the transcriptomic signature of incoming monocytes in a partially Trem1-dependent mechanism

PROVIDER: PRJNA548348 | ENA |

REPOSITORIES: ENA

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Small intestinal inflammation shapes the transcriptomic signature of incoming monocytes in a partially Trem1-dependent mechanism

Project description:In this study we showed that Trem1 is one of genes that were differentially regulated in donor monocytes recovered from non-inflamed and inflamed small intestine of recipient mice. We, therefore, aimed at investigating the role of Trem1 on regulating the monocyte adapatation and differentiation in a context-dependent manner. Thus, the gene expression of WT and Trem1-deficient donor monocytes that are recruited to non-inflamed and inflamed small intestine one day after transfer.

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Transcription profiling of human monocytes after treatment vehicle, isotype control antibody, TREM1 antibody, LPS, isotype control antibody plus LPS and TREM1 antibody plus LP to invesigate innate immune responses to TREM-1 activation

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