Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus

ABSTRACT: A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus

PROVIDER: PRJNA549529 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus

Project description:A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus

| PRJNA549530 | ENA

Genetic contributions of lupus nephritis in a multi-ethnic cohort of systemic lupus erythematosus (SLE)

Project description:Genetic contributions of lupus nephritis in a multi-ethnic cohort of systemic lupus erythematosus (SLE)

| PRJNA472420 | ENA

Genetic contributions of lupus nephritis in a multi-ethnic cohort of systemic lupus erythematosus (SLE)

Project description:Genetic contributions of lupus nephritis in a multi-ethnic cohort of systemic lupus erythematosus (SLE)

| PRJNA472421 | ENA

A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus.

Project description:Systemic lupus erythematous (SLE) is a heterogeneous autoimmune disease in which outcomes vary among different racial groups. Here, we aim to identify SLE subgroups within a multiethnic cohort using an unsupervised clustering approach based on the American College of Rheumatology (ACR) classification criteria. We identify three patient clusters that vary according to disease severity. Methylation association analysis identifies a set of 256 differentially methylated CpGs across clusters, including 101 CpGs in genes in the Type I Interferon pathway, and we validate these associations in an external cohort. A cis-methylation quantitative trait loci analysis identifies 744 significant CpG-SNP pairs. The methylation signature is enriched for ethnic-associated CpGs suggesting that genetic and non-genetic factors may drive outcomes and ethnic-associated methylation differences. Our computational approach highlights molecular differences associated with clusters rather than single outcome measures. This work demonstrates the utility of applying integrative methods to address clinical heterogeneity in multifactorial multi-ethnic disease settings.

| S-EPMC6715644 | biostudies-literature

Systemic lupus erythematosus

Project description:Systemic lupus erythematosus

| PRJNA203032 | ENA

Systemic Lupus Erythematosus Subtypes in a Multi-Ethnic Cohort

Project description:<p>Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organ systems and varies in severity across different populations. To examine the clinical heterogeneity of SLE, we sought to identify different lupus subtypes within our multi-ethnic cohort using a clustering approach. Additionally, with genome-wide methylation and genotype data generated for our cohort, we applied integrative methods to investigate genetic and epigenetic risk factors. This integrative and computational approach revealed molecular differences associated with phenotypic clusters. </p>

| phs001850 | dbGaP

Spatial transcriptomics of Cutaneous and Systemic Lupus Erythematosus skin

Project description:We performed spatial transcriptomics on a case series of different clinical subtypes of cutaneous lupus erythematosus including acute cutaneous lupus erythematosus (malar rash, systemic lupus erythematosus). Our goals were to (1) determine which differentially expressed genes (DEGs) could be attributed to specific cell populations in specific locations within the tissue, (2) determine if spatial transcriptomics could better distinguish between CLE clinical subtypes than bulk RNA approaches and (3) examine potential cell-cell communication pathways within the skin lesions.

2021-10-01 | GSE182825 | GEO

Gene expression analysis in canine discoid/chronic lupus erythematosus, mucocutaneous lupus erythematosus and pyoderma

Project description:We performed a comparative immunology case study of client-owned dogs to determine if immune and skin gene expression profiles in spontaneous canine cutaneous lupus erythematosus mirror those observed in human cutaneous lupus.

2022-03-23 | GSE160260 | GEO

PAGE Multi-Ethnic Cohort Study

Project description:PAGE Multi-Ethnic Cohort Study

| PRJNA75617 | ENA

Transcription profiling of BXSB mice to study lupus erythematosus

Project description:Genetic basis of systemic lupus erythematosus in BXSB mice.

2013-01-30 | E-MIMR-7 | biostudies-arrayexpress