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RNA seq on SP specific CD8+ T cells, Ly49+ and Ly49-CD8+ T cells from MOG and MOG + SP immunized mice and DNA sequencing for multiple rounds of the pMHC-yeast display selection for TCR6, TCR7 and FluTCR

ABSTRACT: RNA seq on SP specific CD8+ T cells, Ly49+ and Ly49-CD8+ T cells from MOG and MOG + SP immunized mice and DNA sequencing for multiple rounds of the pMHC-yeast display selection for TCR6, TCR7 and FluTCR

PROVIDER: PRJNA551265 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9036490_1.fastq.gz	Fastqsanger.gz
	SRR9036490_2.fastq.gz	Fastqsanger.gz
	SRR9036491_1.fastq.gz	Fastqsanger.gz
	SRR9036491_2.fastq.gz	Fastqsanger.gz
	SRR9036492_1.fastq.gz	Fastqsanger.gz

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RNA seq on SP specific CD8+ T cells, Ly49+ and Ly49-CD8+ T cells from MOG and MOG + SP immunized mice [RNA-Seq]

Project description:RNA seq on SP specific CD8+ T cells, Ly49+ and Ly49-CD8+ T cells from MOG and MOG + SP immunized mice [RNA-Seq]

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RNA seq on SP specific CD8+ T cells, Ly49+ and Ly49-CD8+ T cells from MOG and MOG + SP immunized mice [RNA-Seq]

Project description:In experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), induction generates successive waves of clonally expanded CD4+, CD8+, and gd+ T cells in the blood and central nervous system, similar to gluten challenge studies of Celiac patients. In MS patients, we also observe major expansions of CD8+ T cells. In EAE, we find that most expanded CD4+ T cells are specific for the inducing myelin peptide MOG35-55 but in contrast, peptide ligands derived from a yeast peptide-MHC display library for some of the clonally expanded CD8+ T cells inhibit disease by suppressing the proliferation of MOG-specific CD4+ T cells. These results suggest the induction of autoreactive CD4+ T cells triggers an opposing mobilization of regulatory CD8+ T cells.

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RNA seq on SP specific CD8+ T cells, Ly49+ and Ly49-CD8+ T cells from MOG and MOG + SP immunized mice and DNA sequencing for multiple rounds of the pMHC-yeast display selection for TCR6, TCR7 and FluTCR

Project description:This SuperSeries is composed of the SubSeries listed below.

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DNA sequencing for multiple rounds of the pMHC-yeast display selection for TCR6, TCR7 and FluTCR [other]

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Epigenetic evolution of the Ly49 gene family [nanoCAGE]

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