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Gene expression data from human omental adipose tissue

ABSTRACT: Gene expression data from human omental adipose tissue

PROVIDER: PRJNA552106 | ENA |

REPOSITORIES: ENA

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Gene expression data from human omental adipose tissue

Project description:Among 226 morbidly obese patients who underwent gastric bypass surgery between 2013 and 2014 as part of the A Biological Atlas of Severe Obesity (ABOS) study (ClinicalTrials.gov; NCT01129297), 18 women who gave informed consent were recruited in this study for immunophenotyping and microarray analyses of omental adipose tissue (AT). We characterized T and NK cell populations in omental AT from morbidly obese women with varying levels of IR. AT IFN-gamma NK cells, but not CD4, CD8 or gamma delta T cells, were positively correlated with glucose levels, glycated hemoglobin (HbA1c), and IR. AT NK cells were linked to a pro-inflammatory gene expression profile in AT and developed an effector phenotype in response to IL-12 and IL-15. Moreover, integrated transcriptomic analysis revealed a potential implication of AT IFN-gamma NK cells in controlling adipose tissue inflammation, remodeling, and lipid metabolism, suggesting that NK cells are involved in metabolic homeostasis in visceral AT in humans.

2022-06-01 | GSE133666 | GEO

Expression data from human omental and subcutaneous adipose tissue taken from volunteers undergoing bariatric surgery

Project description:This SuperSeries is composed of the following subset Series: GSE29409: Subcutaneous and omental white adipose tissue biopsies analysed from five obese patients GSE29410: Subcutaneous and omental white adipose tissue biopsies analysed from three obese patients Refer to individual Series

2012-01-01 | E-GEOD-29411 | biostudies-arrayexpress

snRNA-seq data on human subcutaneous and omental white adipose tissue

Project description:We generated single nucleus transcriptomic atlas for human subcutaneous and omental white adipose tissue (WAT).

2023-02-23 | GSE225700 | GEO

Effects of rosiglitazone on human omental adipose tissue gene expression

Project description:Effects of rosiglitazone on human omental adipose tissue gene expression

| PRJNA506075 | ENA

Gene expression analysis of subcutaneous and omental adipose tissue from obese, insulin-resistant women

Project description:The association between central obesity and insulin resistance reflects the properties of visceral adipose tissue. Our aim was to gain further insight into this association by analysing the lipid composition of subcutaneous and omental adipose tissue in obese women with and without insulin resistance. Subcutaneous and omental adipose tissue and serum were obtained from 29 obese nondiabetic women, 13 of whom were hyperinsulinemic. Histology, and lipid and gene profiling were performed. In omental adipose tissue of obese, insulin-resistant women, adipocyte hypertrophy and macrophage infiltration were accompanied by an increase in GM3 ganglioside and its synthesis enzyme ST3GAL5; in addition, phosphatidylethanolamine (PE) lipids were increased and their degradation enzyme, PEMT, decreased. ST3GAL5 was expressed predominantly in adipose stromovascular cells and PEMT in adipocytes. Insulin resistance was also associated with an increase in PE lipids in serum. Total RNA was isolated and up to 400 ng of total RNA per sample was labelled and hybridized to Illumina HumanHT-12_V4 expression BeadChip platform. Paired subcutaneous and omental samples from 6 women were analysed.

2015-12-07 | E-GEOD-73108 | biostudies-arrayexpress

Gene expression analysis of subcutaneous and omental adipose tissue from obese, insulin-resistant women

2015-12-07 | GSE73108 | GEO

Differential gene expression in omental adipose tissue from obese children

Project description:Characterization of genes associated with adipose tissue is key to understanding the pathogenesis of obesity and developing treatments for this disorder. Differential gene expression in the adipose tissue has been described in adulthood but none studies have been developed on childhood. The purpose of this study was to compare gene expression in omental adipose tissue from obese prepubertal and normal weight children. We selected 5 obese (BMI adjusted for age and sex z score >2) and 6 normal weight children. RNA was extracted from omental adipose tissue biopsies and cRNA was hybridizated on the human genome U133 Plus 2.0 Arrays (Affymetrix®). Microarray experiments were performed for each sample, and selected group of gene expression values were confirmed with real-time RT-PCR in 10 obese and 10 normal weigth prepubertal children. 1276 genes were found to be differentially expressed at P<0.05. Of those differential genes, 201 were upregulated (Fc>2) and 42 were downregulated (Fc<-2). Genes involved in metabolic and signalling pathways were altered in childhood obesity. Keywords: disease state analysis

2008-10-01 | GSE9624 | GEO

Gene expression analysis of omental and mesenteric adipose tissue in Crohn's disease and ulcerative colitis

Project description:Our hypothesis is that in IBD patients intestinal bacteria translocation into the intra-abdominal fat depots affects adipocyte morphology and gene expression. The study aimed to study adipocyte gene expression of omental (OM) and mesenteric (MES) adipose tissue of ulcerative colitis (UC) and crohn's disease (CD). Total RNA was extracted from isolated adipocytes from omental and mesenteric adipose tissue of CD and UC patients. Microarray experiments were performed in duplicates of 4 different pools of RNAs extracted from adipocytes isolated from OM and MES of UC patients (n=5) and CD patients (n=5) respectively.

2013-05-09 | E-GEOD-46754 | biostudies-arrayexpress

snRNA-seq data on human subcutaneous and omental white adipose tissue

Project description:snRNA-seq data on human subcutaneous and omental white adipose tissue

| PRJNA937185 | ENA

Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans

Project description:Adipose tissues play an important role in the pathophysiology of obesity-related disease including type 2 diabetes. To describe gene expression patterns and functional pathways in obesity-related type 2 diabetes, we performed global transcript profiling of omental adipose tissue in morbidly obese individuals with or without diabetes.

2015-07-29 | GSE71416 | GEO

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