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Gene expression data from human omental adipose tissue

ABSTRACT: Among 226 morbidly obese patients who underwent gastric bypass surgery between 2013 and 2014 as part of the A Biological Atlas of Severe Obesity (ABOS) study (ClinicalTrials.gov; NCT01129297), 18 women who gave informed consent were recruited in this study for immunophenotyping and microarray analyses of omental adipose tissue (AT). We characterized T and NK cell populations in omental AT from morbidly obese women with varying levels of IR. AT IFN-gamma NK cells, but not CD4, CD8 or gamma delta T cells, were positively correlated with glucose levels, glycated hemoglobin (HbA1c), and IR. AT NK cells were linked to a pro-inflammatory gene expression profile in AT and developed an effector phenotype in response to IL-12 and IL-15. Moreover, integrated transcriptomic analysis revealed a potential implication of AT IFN-gamma NK cells in controlling adipose tissue inflammation, remodeling, and lipid metabolism, suggesting that NK cells are involved in metabolic homeostasis in visceral AT in humans.

ORGANISM(S): Homo sapiens

PROVIDER: GSE133666 | GEO | 2022/06/01

REPOSITORIES: GEO

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