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Genetic Predictors of Polybrominated biphenyl (PBB) Elimination

ABSTRACT: Genetic Predictors of Polybrominated biphenyl (PBB) Elimination

PROVIDER: PRJNA553007 | ENA |

REPOSITORIES: ENA

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Genetic Predictors of Polybrominated biphenyl (PBB) Elimination

Project description:Genetic Predictors of Polybrominated biphenyl (PBB) Elimination

| PRJNA553008 | ENA

Exposure to polybrominated biphenyl (PBB) associates with DNA methylation differences across the genome

Project description:Polybrominated biphenyl (PBB) is an endocrine-disrupting compound which was accidently added to the food supply in Michigan in the 1970’s. Highly exposed individuals and their children have numerous health problems, though the underlying mechanism behind these health problems remains unknown. Other endocrine-disrupting compounds have been linked to epigenetic differences, but no epigenetic studies have been done for PBB. In this study, DNA from the blood of individuals with PBB exposure from the Michigan PBB Registry was interrogated with the MethylationEPIC BeadChip (N = 659). Associations between each of the ~850,000 CpG sites and current, serum PBB levels were tested with a linear regression that controlled for age, sex, and cell type proportions. We show that exposure to PBB is associated with differences in epigenetic marks that suggest that it is acting similarly to estrogen and is associated with dysregulated immune system pathways.

2018-08-01 | GSE116339 | GEO

Exposure to polybrominated biphenyl (PBB) associates with DNA methylation differences across the genome

Project description:Exposure to polybrominated biphenyl (PBB) associates with DNA methylation differences across the genome

| PRJNA478257 | ENA

Environmental exposure to polybrominated biphenyl (PBB) associates with an increased rate of biological aging.

Project description:Advanced age increases risk for cancer, cardiovascular disease, and all-cause mortality. However, people do not age at the same rate, and biological age (frequently measured through DNA methylation) can be older than chronological age. Environmental factors have been associated with the rate of biological aging, but it is not known whether persistent endocrine-disrupting compounds (EDCs) like polybrominated biphenyl (PBB) would associate with age acceleration. Three different epigenetic age acceleration measures (intrinsic, extrinsic, and phenotypic) were calculated from existing epigenetic data in whole blood from a population highly exposed to PBB (N=658). Association between serum PBB concentration and these measures was tested, controlling for sex, lipid levels, and estimated cell type proportions. Higher PBB levels associated with increased age acceleration (intrinsic: β=0.24, 95%CI=0.01-0.46, p = 0.03; extrinsic: β=0.39, 95%CI=0.12-0.65, p = 0.004; and phenotypic: β=0.30, 95%CI=0.05-0.54, p = 0.01). Neither age when exposed to PBB nor sex statistically interacted with PBB to predict age acceleration, but, in stratified analyses, the association between PBB and age acceleration was only in people exposed before finishing puberty and in men. This suggests that EDCs can associate with the biological aging process, and further studies are warranted to investigate other environmental pollutants' effect on aging.

| S-EPMC6710070 | biostudies-literature

Exposure to polybrominated biphenyl (PBB) associates with genome-wide DNA methylation differences in peripheral blood.

Project description:In 1973, Michigan residents were exposed to polybrominated biphenyl (PBB) when it was accidentally added to farm animal feed. Highly exposed individuals and their children have experienced endocrine-related health problems, though the underlying mechanism behind these remains unknown. We investigated whether PBB exposure is associated with variation in DNA methylation in peripheral blood samples from 658 participants of the Michigan PBB registry using the MethylationEPIC BeadChip, as well as investigated what the potential function of the affected regions are and whether these epigenetic marks are known to associate with endocrine system pathways. After multiple test correction (FDR <0.05), 1890 CpG sites associated with total PBB levels. These CpGs were not enriched in any particular biological pathway, but were enriched in enhancer and insulator regions, and depleted in regions near the transcription start site or in CpG islands (p < 0.05). They were also more likely to be in ARNT and ESR2 transcription factor binding sites (p = 3.27e-23 and p = 1.62e-6, respectively), and there was significant overlap between CpGs associated with PBB and CpGs associated with estrogen (p < 2.2e-16). PBB-associated CpGs were also enriched for CpGs known to be associated with gene expression in blood (eQTMs) (p < 0.05). These eQTMs were enriched for pathways related to immune function and endocrine-related autoimmune disease (FDR <0.05). These results indicate that exposure to PBB is associated with differences in epigenetic marks that suggest that it is acting similarly to estrogen and is associated with dysregulated immune system pathways.

| S-EPMC6380401 | biostudies-literature

Polybrominated diphenyl ethers (PBDEs)

Project description:Polybrominated diphenyl ethers (PBDEs)

| PRJNA489665 | ENA

Rhododoccus jostii RHA1 was grown in the sterilized soil with biphenyl

Project description:Transcriptomic analysis of the cells grown on biphenyl in the sterilized soil and those grown on biphenyl to mid-exponential phase in a liquid medium

2010-06-10 | GSE22240 | GEO

Effects of biphenyl on Rhodococcus sp. RHA1

Project description:two cultures one grown on biphenyl and other on pyruvate Keywords: growth type

2006-11-01 | GSE5268 | GEO

Proteomics of biphenyl labelling study

Project description:protein based stable isotope probing was performed for identifying microorganisms actually responsible for biphenyl biodegradation in soil environment.

2022-02-16 | PXD023646 | Pride

stationary phase, Rhododoccus jostii RHA1 was grown in W minimal liquid medium with biphenyl

Project description:Transcriptomic analysis of the cells grown on biphenyl to stationary phase and those grown on biphenyl to mid-exponential phase

2010-06-10 | GSE22238 | GEO

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