Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Circulatory proteins permeate the brain via selective transport impaired with age"

ABSTRACT: Circulatory proteins permeate the brain via selective transport impaired with age"

PROVIDER: PRJNA553575 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9662150_1.fastq.gz	Fastqsanger.gz
	SRR9662150_2.fastq.gz	Fastqsanger.gz
	SRR9662160_1.fastq.gz	Fastqsanger.gz
	SRR9662160_2.fastq.gz	Fastqsanger.gz
	SRR9662170_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 1490

Similar Datasets

Circulatory proteins permeate the brain via selective transport impaired with age

Project description:Circulatory proteins permeate the brain via selective transport impaired with age

| PRJNA597213 | ENA

Circulatory proteins permeate the brain via selective transport impaired with age"

Project description:single cell RNAseq of 3 month mouse brain endothelial cells

2020-07-01 | GSE134058 | GEO

Circulatory proteins permeate the brain via selective transport impaired with age

Project description:10x single-cell RNA-sequencing to profile the transcriptomic response of the brain endothelium to pharmacologic ALPL inhibition

2020-07-01 | GSE142500 | GEO

Rejuvenating Age-impaired Fracture Healing

Project description:Rejuvenating Age-impaired Fracture Healing

| PRJNA722249 | ENA

Phosphoglycerate dehydrogenase causes electron transport chain defect via impaired heme synthesis: RNA sequencing.

Project description:Phosphoglycerate dehydrogenase causes electron transport chain defect via impaired heme synthesis: RNA sequencing.

| PRJEB18808 | ENA

Impaired T3 transport and action underlies the pathophisiology of the Allan-Herdon-Dudley syndrome

Project description:Impaired T3 transport and action underlies the pathophisiology of the Allan-Herdon-Dudley syndrome

| PRJNA1065480 | ENA

IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport

Project description:Mutations in the IER3IP1 (Immediate early response-3 interacting protein 1) gene can cause MEDS1 (microcephaly with simplified gyral pattern, epilepsy, and permanent neonatal diabetes syndrome-1), a severe disease leading to death in early childhood. The small endoplasmic reticulum-membrane protein IER3IP1 has a non-essential role in ER-Golgi transport. We here use secretome and cell-surface proteomics to show that the loss of IER3IP1 or expression of the pathogenic p.L78P-mutation causes ER retention of selective cell-surface receptors and secreted proteins involved in neuronal migration. This correlates with distension of ER membranes and increased lysosomal activity. Trafficking of the cargo receptor ERGIC53 and of KDEL-receptor 2 are impaired, the latter causing the aberrant secretion of ER-localized chaperones. In utero knock-down of IER3IP1 in brains of mouse embryos displays a morphological phenotype of newborn neurons. Taken together, our data provide hints on how the loss or mutation of a 10 kDa small ER-membrane protein can cause a fatal syndrome.

2023-12-01 | MSV000093547 | MassIVE

Brain endothelial cells are exquisite sensors of age-related circulatory cues

Project description:Brain endothelial cells are exquisite sensors of age-related circulatory cues

| PRJNA610331 | ENA

Transcriptional profiling of circulatory monocytes in community-acquired pneumonia

Project description:In this study, we sought to broaden our understanding of circulatory monocyte functions captured during the acute (on hospital admission; day0) and recovery (one month follow-up) stages of patients diagnosed with community-acquired pneumonia (CAP).

2021-08-05 | GSE160329 | GEO

Heart failure patients' peripheral blood mononuclear cell gene expression profiles before mechanical circulatory support

Project description:This data represents whole transcriptome total RNA gene expression profiles of peripheral blood mononuclear cells collected from 29 advanced heart failure patients on the day before undergoing mechanical circulatory support surgery. Keywords = Advanced Heart Failure. Keywords = Mechanical Circulatory Support. Keywords = Biological Age. Keywords = PBMC. Keywords = Immune Response. Keywords = Peripheral Blood. Keywords =Organ Function. Keywords = Recovery. Organism: Homo sapiens. Type: Expression profiling by array. Platforms: Illumina HiSeq 2500.

2018-02-13 | GSE104423 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data