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Stress-induced RNA–chromatin interactions promote endothelial dysfunction

ABSTRACT: Stress-induced RNA–chromatin interactions promote endothelial dysfunction

PROVIDER: PRJNA558554 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12462453_1.fastq.gz	Fastqsanger.gz
	SRR12462453_2.fastq.gz	Fastqsanger.gz
	SRR12462454_1.fastq.gz	Fastqsanger.gz
	SRR12462454_2.fastq.gz	Fastqsanger.gz
	SRR12462459.fastq.gz	Fastqsanger.gz

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Stress-induced RNA–chromatin interactions promote endothelial dysfunction (iMARGI)

Project description:Chromatin-associated RNA (caRNA) has been proposed as a type of epigenomic modifier. Here, we test whether environmental stress can induce cellular dysfunction through modulating RNA-chromatin interactions. We induce endothelial cell (EC) dysfunction with high glucose and TNFα (H + T), that mimic the common stress in diabetes mellitus. We characterize the H + T-induced changes in gene expression by single cell (sc)RNA-seq, DNA interactions by Hi-C, and RNA-chromatin interactions by iMARGI. H + T induce inter-chromosomal RNA-chromatin interactions, particularly among the super enhancers. To test the causal relationship between H + T-induced RNA-chromatin interactions and the expression of EC dysfunction-related genes, we suppress the LINC00607 RNA. This suppression attenuates the expression of SERPINE1, a critical pro-inflammatory and pro-fibrotic gene. Furthermore, the changes of the co-expression gene network between diabetic and healthy donor-derived ECs corroborate the H + T-induced RNA-chromatin interactions. Taken together, caRNA-mediated dysregulation of gene expression modulates EC dysfunction, a crucial mechanism underlying numerous diseases.

2020-08-17 | GSE135355 | GEO

Stress-induced RNA–chromatin interactions promote endothelial dysfunction (scRNA-seq human vascular)

Project description:Stress-induced RNA–chromatin interactions promote endothelial dysfunction (scRNA-seq human vascular)

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Stress-induced RNA–chromatin interactions promote endothelial dysfunction (Hi-C)

2020-08-17 | GSE135354 | GEO