Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MiRNA Analysis of lungs of LCPUFA-treated asthmatic C57BL/6 mice and respective controls

ABSTRACT: miRNA Analysis of lungs of LCPUFA-treated asthmatic C57BL/6 mice and respective controls

PROVIDER: PRJNA559388 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9934130.fastq.gz	Fastqsanger.gz
	SRR9934140.fastq.gz	Fastqsanger.gz
	SRR9934131.fastq.gz	Fastqsanger.gz
	SRR9934141.fastq.gz	Fastqsanger.gz
	SRR9934132.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

miRNA Analysis of lungs of LCPUFA-treated asthmatic C57BL/6 mice and respective controls

Project description:Next generation sequencing (NGS) results demonstrate the modulative capacity of LCPUFAs on dysregulated miRNA expression in asthma. Methods: Sequencing of miRNA was performed by NGS from lung tissue of asthmatic and control mice with normal diet, as well as of LCPUFA supplemented asthmatic mice using Illumina miSeq. Conclusion: Our results demonstrate the modulative capacity of LCPUFAs on dysregulated miRNA expression in asthma.

2019-12-31 | GSE135597 | GEO

Comparative analysis of gene expression in C57BL/6J and DBA/2J aging lungs.

Project description:We hypothesize that gene expression in the aging lungs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes. More specifically, (1) Aging DBA/2J mice compared to aging C57BL/6 mice are known to be accelerated in their lung physiology and morphometry; (2) C57BL/6J are known to have longer natural longevity than DBA/2J mice. In order to test these hypotheses at the gene expression level, we utilized microarray analysis to examine transcriptional differences between aging lungs of both strains of mice. Keywords: comparative expression profiling

2007-08-31 | GSE6591 | GEO

Transcriptional respose at 18hrs in Interferon treated lungs from C57BL/6 wt mice

Project description:We used microarrays to analyse the global programme of gene expression in response to intranasal interferon treatment (IFNa4 and IFNl2) in lungs from C57BL/6 wt mice

2016-11-22 | GSE70628 | GEO

Rhinoviruses and enterovirus-D68 replicate more robustly in respiratory tissues originating from asthmatic patients compared to non-asthmatic controls

Project description:Investigation of the mechanism leading to differential rhinovirus infection in airway epithelia from healty versus asthmatic patients

2023-02-13 | GSE222129 | GEO

Transcriptional response in influenza-infected lungs from C57BL/6 wt, 129S7 wt and IFNAR-/- (129) mice

Project description:We used microarrays to analyse the global program of gene expression in response to Influenza A (X31) infection in lungs from C57BL/6 wt, 129S7 wt and IFNAR-/- (129) mice.

2014-04-30 | GSE55403 | GEO

Transcriptional response in influenza-infected lungs from C57BL/6 wt, 129S7 wt and IFNAR-/- (129) mice

Project description:We used microarrays to analyse the global program of gene expression in response to Influenza A (X31) infection in lungs from C57BL/6 wt, 129S7 wt and IFNAR-/- (129) mice. Mock- or 5 day influenza A (X31)-infected total lungs from mice with the indicated genotypes were collected and processed for expression profiling.

2014-04-30 | E-GEOD-55403 | biostudies-arrayexpress

The crucial role of CPT2 in the asthmatic bronchial smooth muscle remodeling

Project description:Asthma is a very frequent airway disease that affects 6 to 20% of the population. Severe asthma, represents 3 to 5% of all asthmatic patients and is histologically characterized by an increased bronchial smooth muscle (BSM) mass and clinically by viral exacerbations. Functionally, BSM remodeling had a poor prognostic value in asthma, since higher BSM mass was associated with lower lung function and increased exacerbation rate. However, the role of BSM as a potential actor of asthma exacerbation has only been sparsely suggested. Thus, we hypothesis that asthmatic BSM cell metabolism is modified compare to that of non-asthmatic and that could be a potential target to reduce asthmatic BSM cell proliferation and remodeling in asthma.

2021-06-10 | PXD015566 | Pride

FluOMICS - Metabolomics analysis of mouse lungs infected with H1N1 influenza virus

Project description:Metabolomics analysis of C57BL/6 mouse lungs infected with influenza A/California/04/09 (H1N1) virus, mock infected with PBS, or untreated.

2017-12-06 | MSV000081785 | MassIVE

Global transcriptome analysis reveals aging-related genes in Atp8b1 mutant lungs

Project description:Aging is associated with progressive decline in lung function and responses to environmental stress culminating in increased incidence of lung diseases. Initial analysis of Atp8b1 (ATPase, Aminophospholipid Transporter, Class I, Type 8B, Member 1) mutant mice (on C57BL/6J background) revealed deficiency in transporter function and was associated with decreased lung function. Therefore, to further study the aging-related genes in the lungs at the molecular level, the transcriptome analysis of Atp8b1 mutant and C57BL/6J lungs were carried out at 14 M and 7_9 wks of age. Global transcriptome analysis revealed 532 differentially expressed genes in Atp8b1 mutant lungs, 157 differentially expressed genes in C57BL/6J mice and 37 overlapping genes. Interestingly, the majority of age-related (350) genes were unique to Atp8b1 mutant lungs in contrast to the 85 genes that were unique to C57BL/6J lungs. Further, Ingenuity Pathway Analysis (IPA) of aged genes in Atp8b1 mutant lungs showed enrichment of canonical signaling pathways such as xenobiotic metabolism signaling and Nrf2-mediated signaling pathway. We validated Adamts2 and Mmp13 in Atp8b1 mutant lungs by quantitative real-time PCR (qRT-PCR). In addition, Col1a1 and CxCr6 were also validated in both Atp8b1 mutant and C57BL/6J lungs, respectively. To summarize, our study provide insights into altered age-related genes in Atp8b1 lungs that are associated with mutation and environmental trigger when compared to C57BL/6J lungs.

2016-04-27 | GSE80680 | GEO

RNA sequencing of Asthmatic Human Airway Smooth Muscle Cells I

Project description:The goal of the was to evaluate the mRNA expression profile of non-asthmatic and asthmatic airway smooth muscle.

2018-10-22 | GSE119578 | GEO