Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Enterovirus 71 oncolysis of malignant gliomas

ABSTRACT: Enterovirus 71 oncolysis of malignant gliomas

PROVIDER: PRJNA562271 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10022372.fastq.gz	Fastqsanger.gz
	SRR10022373.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Enterovirus 71 oncolysis of malignant gliomas

Project description:This study finds that EV71 has oncolytic activity against experimental human malignant gliomas. RNA-seq analysis of infected glioma cells reveals transcriptional up-regulation, notably genes in apoptosis pathways. Application of virus targeting based on brain-specific microRNA-124 enhances the safety profile. Oncolysis with EV71 may be a potentially novel treatment for malignant gliomas.

2019-08-27 | GSE136330 | GEO

Scavenger receptor B2 is a cellular receptor for enterovirus 71

Project description:Enterovirus 71 (EV71) belongs to human enterovirus species A of the genus Enterovirus within the family Picornaviridae. We established transformant cells by transfection of mouse cells with genomic DNA from human cells and then detected two EV71-susceptible cell lines. Using microarray with the two cell lines we found that scavenger receptor B2 is a cellular receptor for EV71.

2009-06-21 | GSE16358 | GEO

Gene expression profiles of mice dendritic cell infected by Enterovirus 71

Project description:Investigate the changes of Gene expression profiling in mice infected with Enterovirus 71 dendritic cell in vitro

2021-12-01 | GSE142260 | GEO

Infection with Enterovirus 71 induces modulation of the microRNA profile of the mouse brain

Project description:To further understand the molecular pathogenesis of Enterovirus 71 infection, we profiled cellular microRNAs of brain tissue from suckling Kunming mice infected with EV71 and uninfected mice as comparison.

2016-10-23 | GSE89070 | GEO

Pathological Features of Enterovirus 71-associated Brain and Lung Damage in Mice Based on Quantitative Proteomic Analyses

Project description:Enterovirus 71 (EV71), a member of the Enterovirus genus in the Picornaviridae family, was first recognized as a dermotrophic virus that usually cause mild, self-limiting hand-foot-and-mouth disease (HFMD). However, EV71 infection can sometimes induce a variety of severe neurological complications, pulmonary edema and even death. Here, we aimed to provide an overview of proteomics characterization of EV71-infected brain and lung tissues.

2021-09-10 | PXD023819 | Pride

GNPS - Metabolic detection of malignant brain gliomas through lipidomic analysis

Project description:Lipidomic analysis of malignant brain gliomas to search for biomarkers.

2020-07-05 | MSV000085693 | GNPS

TMT-Based quantitative proteomics analysis of human nerve cells (U251 cells) infected by enterovirus 71 in vitro

Project description:This study used TMT-based quantified proteome method to identify differentially expressed proteins following enterovirus 71 infected of human nerve cells (U251 cells)

2021-01-11 | PXD023496 |

Transcriptomic analysis of SH-SY5Y cells in response to enterovirus type 71 infection

Project description:Today, the pathogenesis of human enterovirus type 71 (HEV71) infection in human central neural system remains unclear. HEV71 is the major pathogen of hand-foot-and-mouth disease (HFMD), and has been associated with severe neurological disease and even death in infants and young children. We employed the human whole genome microarray analyze the transcriptome profiling inhuman neuroblastoma cells SH-SY5Y infected with HEV71. The results showed that HEV71 infection lead to altered expression of 161 human mRNAs including 74 up-regulated genes and 87 down-regulated genes. Then we found that the possible roles of the differentially regulated mRNAs in selected pathways including cell cycle/proliferation, apoptosis, and cytokine/chemokine responses by Bioinformatic analysis. Furthermore, we validated the microarray results by real-time RT-PCR with high identity. Overall, our results provided fundamental information about host response to HEV71 infection in human neuroblastoma cells, and this finding will help to understand the pathogenesis of HEV71 infection and virus-host interaction.

2013-10-31 | GSE45589 | GEO

Mild, moderate and severe enterovirus 71 (EV71) isolates infection in human PBMCs

Project description:Hand, foot and mouth disease (HFMD), caused by enterovirus 71 (EV71), presents mild to severe disease, and sometimes fatal neurological and respiratory manifestations. However, reasons for the severe pathogenesis remain undefined. To investigate this, infection and viral kinetics of EV71 isolates from clinical disease (mild, moderate and severe) from Sarawak, Malaysia, were characterized in human rhabdomyosarcoma (RD), neuroblastoma (SH-SY5Y) and peripheral blood mononuclear cells (PBMCs). High resolution transcriptomics was used to decipher EV71-host interactions in PBMCs. Ingenuity analyses revealed similar pathways triggered by all EV71 isolates, although the extent of activation varied. Importantly, several pathways were found to be specific to the severe isolate, including triggering receptor expressed on myeloid cells 1 (TREM-1) signaling. Depletion of TREM-1 in EV71-infected PBMCs with peptide LP17 resulted in decreased levels of pro-inflammatory genes, and reduced viral loads for the moderate and severe isolates. Mechanistically, this is the first report describing the transcriptome profiles during EV71 infections in primary human cells, and the involvement of TREM-1 in the severe disease pathogenesis, thus providing new insights for future treatment targets.

2020-03-16 | GSE135964 | GEO

Transcriptomic analysis of SH-SY5Y cells in response to enterovirus type 71 infection

2013-10-31 | E-GEOD-45589 | biostudies-arrayexpress