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Transcriptional Profiling of Lumbar Spinal Cord in a Rat Model of Bone Cancer Pain

ABSTRACT: Transcriptional Profiling of Lumbar Spinal Cord in a Rat Model of Bone Cancer Pain

PROVIDER: PRJNA565189 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10103777_1.fastq.gz	Fastqsanger.gz
	SRR10103777_2.fastq.gz	Fastqsanger.gz
	SRR10103778_1.fastq.gz	Fastqsanger.gz
	SRR10103778_2.fastq.gz	Fastqsanger.gz
	SRR10103779_1.fastq.gz	Fastqsanger.gz

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Transcriptional Profiling of Lumbar Spinal Cord in a Rat Model of Bone Cancer Pain

Project description:Bone cancer pain (BCP), in which the majority is caused by metastasis from other cancer sites, is the most common type of chronic cancer pain. Bone cancer pain is developed accompanied by changes of numerous genes expression, from peripheral to central nervous system, which may account for this dysfunctional nociceptive perception. Although the pivotal role of lncRNA in neuropathic pain are well acknowledged, the involvement of lncRNA in bone cancer pain development are remain to be clarified. Thus, in the present study we performed transcriptome sequencing to explore changes in expression profiles of lncRNA and mRNA to provide a landscape of dysregulated lncRNA and mRNA in spinal cord of bone cancer pain.

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