Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional basis of mouse and human dendritic cell heterogeneity revealed by single-cell profiling

ABSTRACT: Transcriptional basis of mouse and human dendritic cell heterogeneity revealed by single-cell profiling

PROVIDER: PRJNA566350 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10144978_1.fastq.gz	Fastqsanger.gz
	SRR10144978_2.fastq.gz	Fastqsanger.gz
	SRR10144979_1.fastq.gz	Fastqsanger.gz
	SRR10144979_2.fastq.gz	Fastqsanger.gz
	SRR10144980_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 30

Similar Datasets

Transcriptional basis of mouse and human dendritic cell heterogeneity revealed by single-cell profiling

Project description:Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to their unique ability to serve as a principal antigen-presenting cell type capable of initiating T cell responses. Classical dendritic cells have been divided into two subsets, cDC1 and cDC2, based on phenotypic markers and their distinct abilities to prime CD8 and CD4 T cells and direct their differentiation into effectors. Whilst the transcriptional features of the cDC1 subset have been well characterized, the heterogeneity of cDC2 and the development and function of distinct cell types comprising this subset remain poorly understood. Unbiased single-cell RNA sequencing analysis of DCs, combined with genetic reporter expression and fate-mapping revealed two principal cDC2 lineages, their developmental pathways and transcriptional regulators, including the expression of T-bet and RORt, two key transcription factors known to define functional adaptive and innate lymphocyte subsets. The cDC2 lineages were characterized by distinct metabolic and functional programs with phenotypic conservation observed across tissues. Extending the findings in mice to humans revealed conserved characteristics of DC heterogeneity and the presence of the newly defined DC subsets in human autoimmune disease and cancer.

2019-10-25 | GSE137710 | GEO

Developmental Basis of SHH Medulloblastoma Heterogeneity

Project description:Developmental Basis of SHH Medulloblastoma Heterogeneity

| PRJNA885474 | ENA

Heterogeneity of plasmacytoid Dendritic Cells (pDCs) is revealed by a distinct lineage of origin

Project description:Heterogeneity of plasmacytoid Dendritic Cells (pDCs) is revealed by a distinct lineage of origin

| PRJNA470933 | ENA

RNA-seq and ATAC-seq to study dendritic cell heterogeneity

Project description:RNA-seq and ATAC-seq to study dendritic cell heterogeneity

| PRJNA534273 | ENA

Typhoidal Salmonella Dendritic Cell Survival Mechanism Revealed by Dual RNA sequencing

Project description:Typhoidal Salmonella Dendritic Cell Survival Mechanism Revealed by Dual RNA sequencing

| PRJNA679623 | ENA

GNPS - Quantifying Cell Heterogeneity and Subpopulations Using Single Cell Metabolomics

Project description:We combined the Single-probe single cell MS(SCMS) experimental technique with a bioinformatics software package, SinCHet-MS (Single Cell Heterogeneity for Mass Spectrometry), to characterize changes of tumor heterogeneity, quantify cell subpopulations, and prioritize the metabolite biomarkers of each subpopulation.

2023-06-15 | MSV000092178 | GNPS

Single-cell transcriptome profiling reveals macrophage and dendritic cell heterogeneity across six zebrafish organs

Project description:Single-cell transcriptome profiling reveals macrophage and dendritic cell heterogeneity across six zebrafish organs

| PRJNA951670 | ENA

Plasmacytoid dendritic cell heterogeneity is defined by CXCL10 expression following TLR7 stimulation

Project description:Plasmacytoid dendritic cell heterogeneity is defined by CXCL10 expression following TLR7 stimulation

| PRJNA435438 | ENA

Plasmacytoid dendritic cell heterogeneity is defined by CXCL10 expression following TLR7 stimulation

Project description:Plasmacytoid dendritic cell heterogeneity is defined by CXCL10 expression following TLR7 stimulation

| PRJNA453966 | ENA

Clinical trial for safety and tolerability using an interferon-inducible dendritic cell-based vaccine

Project description:Interventions: Dendritic cell-based cancer vaccination;Cancer, dendritic cell, vaccination Primary outcome(s): Safety (adverse reactions, severe adverse events) Study Design: single arm study,open(masking not used),uncontrolled control,single assignment

| 2613751 | ecrin-mdr-crc

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data