Project description:Oral squamous cell carcinoma (OSCC) accounts for the high mortality rate and morbidity in head and neck cancer. Data for analysis were obtained from the microarray data of 6 OSCC tissues, tissues adjacent to cancer, and contralateral normal tissues.We used the affy package under the R environment to preprocess and normalize the original gene chip data.
Project description:Oral squamous cell carcinoma (OSCC) accounts for the high mortality rate and morbidity in head and neck cancer. Data for analysis were obtained from the microarray data of 6 OSCC tissues, tissues adjacent to cancer, and contralateral normal tissues.We used the affy package under the R environment to preprocess and normalize the original gene chip data.
Project description:The development of oral squamous cell carcinoma (OSCC) is a multistep process requiring the accumulation of genetic alterations. Oral carcinogenesis is a multifactorial process involving numerous genetic changes that affect the activity of oncogenes, tumor suppressor genes and other classes of disease-related genes.Therefore, to identify the responsive genes for progression of oral dysplasia or OSCC, we here performed CGH analysis to DNA from oral dysplasia and OSCC by microdissection Copy number analysis of Affymetrix 250K SNP arrays was performed for 8 oral dysplasia samples, 8 oral squamous cell carcinoma samples, using microdissection
Project description:Identification of genes that are differentially regulated in fibroblasts derived from dysplastic oral mucosa and oral squamous cell carcinoma compared to fibroblasts derived from normal oral mucosa. Affymetrix microarrays were used to define differential gene expression. Populations of fibroblasts were isolated from human normal oral mucosa, oral dysplasia and oral squamous cell carcinoma, maintained in 3D collagen I biomatrices, RNA extracted and processed for Affymetrix arrays. Fibroblasts maintained as monolayers were also included as comparators.
Project description:Strand-specific, paired-end, total RNA-sequencing data for fifteen Australian, HPV-negative, young oral squamous cell carcinoma patients of primary tumour and adjacent normal.
Project description:Identification of genes that are differentially regulated in fibroblasts derived from dysplastic oral mucosa and oral squamous cell carcinoma compared to fibroblasts derived from normal oral mucosa. Affymetrix microarrays were used to define differential gene expression.
Project description:Oral cavity squamous cell carcinoma (OSCC) is a disease with extensive morbidity and mortality and few useful molecular targets. Multiplatform integrated genomic analysis was performed in order to identify genomic drivers and molecularly discernible tumor subtypes. mRNA, miRNA and methylation data are all submitted to GEO
Project description:This SuperSeries is composed of the following subset Series: GSE25099: Expression data from 57 patients with oral cancer and 22 normal persons GSE25103: Affymetrix SNP array data for oral squamous cell carcinoma Refer to individual Series