Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A tendon comparative transcriptional atlas

ABSTRACT: A tendon comparative transcriptional atlas

PROVIDER: PRJNA576271 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10241200.fastq.gz	Fastqsanger.gz
	SRR10241300.fastq.gz	Fastqsanger.gz
	SRR10241400.fastq.gz	Fastqsanger.gz
	SRR10241201.fastq.gz	Fastqsanger.gz
	SRR10241301.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 236

Similar Datasets

A tendon comparative transcriptional atlas

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-12-18 | GSE138541 | GEO

Single cell transcriptional atlas of mouse Achilles tendons

Project description:We report a single cell transcriptome atlas of Achilles tendon from 6-week-old male C57Bl/6 mice using single cell RNA sequencing.

2019-10-10 | GSE138515 | GEO

Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues

Project description:Bone marrow aspirate concentrate (BMAC) and adipose-derived stromal vascular fraction (ADSVF) are the most marketed stem cell therapies to treat a variety of conditions in the general population and elite athletes. Both tissues have been used interchangeably clinically even though their detailed composition, heterogeneity, and mechanisms of action have neither been rigorously inventoried nor compared. This lack of information has prevented investigations into ideal dosages and has facilitated anecdata and misinformation. Here, we analyzed single-cell transcriptomes, proteomes, and flow cytometry profiles from paired clinical-grade BMAC and ADSVF. This comparative transcriptional atlas challenges the prevalent notion that there is one therapeutic cell type present in both tissues. We also provide data of surface markers that may enable isolation and investigation of cell (sub)populations. Furthermore, the proteome atlas highlights intertissue and interpatient heterogeneity of injected proteins with potentially regenerative or immunomodulatory capacities.

2024-07-25 | PXD037632 | Pride

Tendon injury

Project description:Tendon injury

| PRJNA1027305 | ENA

Transcriptional atlas of Daphnia magna

Project description:Transcriptional atlas of Daphnia magna

| PRJNA1101019 | ENA

Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues

2024-07-22 | GSE217244 | GEO

RNA-seq of achilles tendon from young and old donors to study age-related changes in tendon

Project description:Tendon from young and old donors was used for RNA-Seq analysis. The aim of the study was to identify differentially expressed tendon transcripts in ageing in order to to characterize molecular mechanisms associated with age-related changes in tendon.

2015-04-01 | E-MTAB-2449 | biostudies-arrayexpress

Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues

Project description:Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues

| PRJNA898260 | ENA

Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch [scRNA-seq]

Project description:We report a high-efficiency differentiation protocol to tendon and fibrocartilage perform molecular profiling of tendon and fibrocartilage fatse in relation to developmetnal in vivo analogues. We also the molecular induction of tendon and fibrocartilage by examining fate dependent and independent gene modules

2021-06-11 | GSE154525 | GEO

Spatial Gene Expression in the Adult Rat Patellar Tendon

Project description:Tendons are dense connective tissues with relatively few cells which makes studying the molecular profile of the tissue challenging. There is not a consensus on the spatial location of various cell types within a tendon, nor the accompanying transcriptional profile. In the present study, we used two male rat patellar tendon samples for sequencing-based spatial transcriptomics to determine the gene expression profile. We integrated our data with a single cell dataset to predict the cell type composition of the patellar tendon as a function of location within the tissue. The spatial location of the predicated cell types suggested that there were two populations of tendon fibroblasts, one located in the tendon midsubstance, while the other localized with red blood cells, pericytes, and immune cells to the tendon peripheral connective tissue. Of the highest expressed spatially variable genes, there were multiple genes with known function in tendon: Col1a1, Col1a2, Dcn, Fmod, Sparc, and Comp. Further, a novel spatially regulated gene (AABR07000398.1) with no known function was identified. The spatial gene expression of tendon associated genes (Scx, Thbs4, Tnmd, Can, Bgn, Lum, Adamts2, Lox, Ppib, Col2a1, Col3a1, Col6a2) was also visualized. Both patellar tendon samples had similar expression patterns for all these genes. This dataset provides new spatial insights into gene expression in a healthy tendon.

2023-11-29 | GSE248646 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data