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Vascular smooth muscle selective deletion of Srf

ABSTRACT: Vascular smooth muscle selective deletion of Srf

PROVIDER: PRJNA577451 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10275323.fastq.gz	Fastqsanger.gz
	SRR10275324.fastq.gz	Fastqsanger.gz
	SRR10275325.fastq.gz	Fastqsanger.gz
	SRR10275326.fastq.gz	Fastqsanger.gz
	SRR10275327.fastq.gz	Fastqsanger.gz

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Vascular smooth muscle selective deletion of Srf

Project description:Previous efforts to conditionally delete the Srf transcription factor in smooth muscle lineages were met with early demise of the mouse due to a gastrointestinal (GI) obstruction phenotype. We have developed a new, more VSMC selective Cre recombinase mouse (Itga8-CreERT2), that circumvents the GI phenotype thus affording the opportunity to evaluate, in an unambiguous manner, VSMC phenotypes where Srf is reduced. The mice live for at least 6 months post-tamoxifen and here we report the first RNA-seq experiments in mouse aortic SMC where Srf is reduced.

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