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FoxO targets in Tsc1-deficient cells under normal food and nutrient restriction food

ABSTRACT: FoxO targets in Tsc1-deficient cells under normal food and nutrient restriction food

PROVIDER: PRJNA577666 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10279800.fastq.gz	Fastqsanger.gz
	SRR10279801.fastq.gz	Fastqsanger.gz
	SRR10279802.fastq.gz	Fastqsanger.gz
	SRR10279803.fastq.gz	Fastqsanger.gz
	SRR10279804.fastq.gz	Fastqsanger.gz

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FoxO targets in Tsc1-deficient cells under normal food and nutrient restriction food

Project description:Exploring downstream regulation by the transcription factor FoxO is necessary to understand its function as a tumor suppressor or promoter in different biological contexts. Here, we employed RNA-seq profiling on single clones isolated using laser capture microdissection from Drosophila larval eye imaginal discs to identify FoxO targets that restrict the proliferation of Tsc1-deficient cells under nutrient restriction (NR).

2020-05-26 | GSE138877 | GEO

Sex-specific resilience of neocortex to food restriction

Project description:Mammals have evolved sex-specific adaptations to reduce energy usage in times of food scarcity. These adaptations are well described for peripheral tissue, though much less is known about how the energy-expensive brain adapts to food restriction, and how such adaptations differ across the sexes. Here, we examined how food restriction impacts energy usage and function in the primary visual cortex (V1) of adult male and female mice. Molecular analysis and RNA sequencing revealed that food restriction modulated canonical, energy-regulating pathways including oxidative phosphorylation, AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling, significantly in males but not in females V1. Moreover, we found that in contrast to males, food restriction in females non-significantly affected V1 ATP usage and visual coding precision (assessed by orientation selectivity). Decreased serum leptin is necessary for triggering energy-saving changes in male mouse V1 during food restriction. Consistent with this result, we found a significant decrease of serum leptin in food-restricted males but no significant change in food-restricted females. Collectively, our findings demonstrate that cortical function and energy usage in female mice are more resilient to food restriction than in males. The neocortex, therefore, contributes to sex-specific, energy-saving adaptations in response to metabolic challenge.

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Leptin and the Placental Response to Maternal Food Restriction during Early Pregnancy

Project description:Concentrations of leptin decline during food restriction. This study was designed to test the hypothesis that some of the effects of maternal food restriction on placental development are mediated by the loss of leptin. Mice were randomized to 3 treatment groups on day 1.5 of pregnancy: (1) ad libitum fed (control) (2) 50% food restriction (restricted) (3) 50% food restriction with leptin replacement (1Âµg/g body weight/day) (leptin). On day 11.5 placentas were collected, and two placentas from each mother were pooled for microarray analysis.

2012-12-07 | E-GEOD-38095 | biostudies-arrayexpress

FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restriction.

Project description:The transcription factor FoxO has been shown to block proliferation and progression in mTORC1-driven tumorigenesis but the picture of the relevant FoxO target genes remains incomplete. Here, we employed RNA-seq profiling on single clones isolated using laser capture microdissection from Drosophila larval eye imaginal discs to identify FoxO targets that restrict the proliferation of Tsc1-deficient cells under nutrient restriction (NR). Transcriptomics analysis revealed downregulation of endoplasmic reticulum-associated protein degradation pathway components upon foxo knockdown. Induction of ER stress pharmacologically or by suppression of other ER stress response pathway components led to an enhanced overgrowth of Tsc1 knockdown tissue. Increase of ER stress in Tsc1 loss-of-function cells upon foxo knockdown was also confirmed by elevated expression levels of known ER stress markers. These results highlight the role of FoxO in limiting ER stress to regulate Tsc1 mutant overgrowth.

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Leptin and the Placental Response to Maternal Food Restriction during Early Pregnancy

2012-12-07 | GSE38095 | GEO

Polymerase II binding analysis during nutrient restriction using targeted DamID

Project description:The adaptable transcriptional response to changes in food availability not only ensures animal survival, but also permits progressing with embryonic development. Interestingly, the central nervous system is preferentially protected to periods of malnutrition, a phenomenon known as ‘brain sparing’. However, the mechanisms that mediates this genetic response remains poorly understood. To get a better understanding of this, we used Drosophila melanogaster as a genetic model, analysing the transcriptional response of larval neural stem cells (neuroblasts) and glial cells of the blood-brain barrier during nutrient restriction using the targeted DamID technique.

2021-07-06 | GSE145055 | GEO

Mild food restriction and gene expression profile (intestine)

Project description:The aim of this study is to obtain the gene expression profiles of the intestine of young growing rats after mild restriction of food intake for one month.

2021-06-08 | GSE176298 | GEO

Mild food restriction and gene expression profile (liver)

Project description:The aim of this study is to obtain the gene expression profiles of the liver of young growing rats after mild restriction of food intake for one week or one month.

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Mild food restriction and gene expression profile (brain)

Project description:The aim of this study is to obtain the gene expression profiles of the brain of young growing rats after mild restriction of food intake for one week or one month.

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