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Transcriptional analysis of tendons from mice with a targeted deletion of scleraxis

ABSTRACT: Transcriptional analysis of tendons from mice with a targeted deletion of scleraxis

PROVIDER: PRJNA579978 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10355701.fastq.gz	Fastqsanger.gz
	SRR10355702.fastq.gz	Fastqsanger.gz
	SRR10355703.fastq.gz	Fastqsanger.gz
	SRR10355704.fastq.gz	Fastqsanger.gz
	SRR10355705.fastq.gz	Fastqsanger.gz

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Transcriptional analysis of tendons from mice with a targeted deletion of scleraxis

Project description:We report RNA sequencing data from the plantaris tendons of adult male mice in the C57Bl/6 background that either have the scleraxis gene (Scx+) or mice in which scleraxis has been deleted using CreERT2 driven from the Rosa26 locus (Scx-). Mice in which scleraxis was deleted were created by crossing scleraxis-floxed mice with Rosa26-CreERT2 mice. Rosa26-CreERT2 mice that did not have a floxed scleraxis allele served as controls. Mice were treated with tamoxifen for 5 days to induce recombination at the scleraxis locus, and then subjected to a synergist ablation procedure in which the Achilles tendon is removed, resulting in compensatory growth of the plantaris tendon. Mice were analyzed either 7 or 14 days after synergist ablation. Control mice that did not undergo tamoxifen treatment or synergist ablation were also studied (NOC).

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