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Staphylococcus hominis strain:SHYJILJH

ABSTRACT: Staphylococcus hominis strain:SHYJILJH Genome sequencing and assembly

PROVIDER: PRJNA580115 | ENA |

REPOSITORIES: ENA

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The ubiquitous human skin commensal Staphylococcus hominis protects against opportunistic pathogens

Project description:Staphylococcus hominis is frequently isolated from human skin and we hypothesize that it may protect the cutaneous barrier from opportunistic pathogens. We determined that S. hominis makes six unique auto inducing peptide (AIP) signals that inhibit the major virulence factor accessory gene regulator (agr) quorum sensing system of Staphylococcus aureus. We solved and confirmed the structures of three novel AIP signals in conditioned media by mass spectrometry, then validated synthetic AIP activity against all S. aureus agr classes. Synthetic AIPs also inhibited the conserved agr system in a related species, Staphylococcus epidermidis. We determined the distribution of S. hominis agr types on healthy human skin and found S. hominis agr-I and agr-II were highly represented across subjects. Further, synthetic AIP-II was protective in vivo against S. aureus-associated dermonecrotic or epicutaneous injury. Together, these findings demonstrate that a ubiquitous colonizer of human skin has a fundamentally protective role against opportunistic damage.

2022-04-04 | GSE199818 | GEO

Staphylococcus hominis subsp. hominis strain:nu4

Project description:Staphylococcus hominis subsp. hominis strain:nu4 Genome sequencing

| PRJNA1051323 | ENA

Staphylococcus hominis strain:MBL_AB63

Project description:Staphylococcus hominis strain:MBL_AB63 Genome sequencing and assembly

| PRJNA687181 | ENA

Staphylococcus hominis strain:H69

Project description:Staphylococcus hominis strain:H69 Genome sequencing and assembly

| PRJNA316465 | ENA

Staphylococcus hominis strain:SH08_17

Project description:Staphylococcus hominis strain:SH08_17 Genome sequencing and assembly

| PRJNA419709 | ENA

Staphylococcus hominis strain:SH04_17

Project description:Staphylococcus hominis strain:SH04_17 Genome sequencing and assembly

| PRJNA419707 | ENA

Staphylococcus hominis strain:RIT612

Project description:Staphylococcus hominis strain:RIT612 Genome sequencing and assembly

| PRJNA503389 | ENA

Staphylococcus hominis strain:C34847

Project description:Staphylococcus hominis strain:C34847 Genome sequencing and assembly

| PRJNA313096 | ENA

Staphylococcus hominis strain:ShoR14

Project description:Staphylococcus hominis strain:ShoR14 Genome sequencing and assembly

| PRJNA717998 | ENA

Staphylococcus hominis strain:MMP2

Project description:Staphylococcus hominis strain:MMP2 Genome sequencing and assembly

| PRJNA304219 | ENA

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