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DNA methylation analysis in malignant melanoma clinical samples [450K array]

ABSTRACT: DNA methylation analysis in malignant melanoma clinical samples [450K array]

PROVIDER: PRJNA588466 | ENA |

REPOSITORIES: ENA

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DNA methylation analysis in malignant melanoma clinical samples [450K array]

Project description:Comprehensive DNA methylation analysis in malignant melanoma clinical samples. Infinium HumanMethylation450 BeadChip was used to obtain DNA methylation profiles across 485,577 CpG sites. Samples included 54 malignant melanoma cases and primary melanocyte culture.

2020-10-22 | GSE140169 | GEO

DNA methylation analysis in malignant melanoma clinical samples [EPIC array]

Project description:DNA methylation analysis in malignant melanoma clinical samples [EPIC array]

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DNA methylation analysis in malignant melanoma clinical samples [EPIC array]

Project description:Comprehensive DNA methylation analysis in malignant melanoma clinical samples and primary melanocyte culture. Infinium MethylationEPIC BeadChip was used to obtain DNA methylation profiles. Samples included 8 malignant melanoma cases and primary melanocyte culture.

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Affymetrix CytoScan HD and OncoScan array data for malignant melanoma samples

Project description:Affymetrix CytoScan HD and OncoScan array data for malignant melanoma samples

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DNA methylation analysis in malignant melanoma clinical samples

Project description:DNA methylation analysis in malignant melanoma clinical samples

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Affymetrix CytoScan HD and OncoScan array data for malignant melanoma samples

Project description:Malignant melanoma is a highly metastatic disease disseminating to several distant sites. This potential is also of great clinical impact for patient survival and therapeutic success. Knowledge about melanoma genomics is mainly based on lymphatic or skin metastases derived data, whereas data from distant sites is rather limited. Therefore, an autopsy-based visceral metastasis biobank was established and an array-based CNV analysis was performed focusing primarily on major organs (brain, lung and liver) on a total of 38 samples (10 primary and 28 organ metastasse). A unique picture emerged about organ specific CNV type distributions or gene alterations including the frequent loss of DNA damage error genes in brain metastases, the presence of HGF/MET autocrine loop in brain and lung metastases, the traces of immunogenic mimicry exclusive for lung metastases or the correlation of BRAF copy number and mutant allele frequency especially in lung metastases. All these above phenomena have a great influence on therapy efficacy or resistance.

2021-12-15 | GSE185165 | GEO

DNA methylation analysis in oropharyngeal cancer [450K array]

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MicroRNA profiling by array of canine oral malignant melanoma and paired normal oral mucosa samples

Project description:total RNAs were extracted from a canine oral malignant melanoma clinical sample (name as 3) and paired normal oral mucosa (name as 3prime) according to the phenol/guanidium thiocyanate method with DNase â treatment. these total RNA were submitted to Filgen, Inc. to perform microRNA microarray.

2011-10-21 | E-MTAB-405 | biostudies-arrayexpress

COHCAP MIRA / 450k Comparison [450k]

Project description:Compare a single sample run with two different technologies: Illumina 450k methylation array and MIRA on NimbleGen

2013-06-08 | GSE42707 | GEO

Infinium Monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis) (methylation array)

Project description:Infinium 450K is a hybridization array designed for the human genome, but the relative conservation between the macaque and human genomes makes its use in macaques feasible. We used the Infinium450K array to assay twelve Cynomolgus macaque muscle biopsies and compared it to Reduced Representation Bisulphite Sequencing (RRBS) data generated on the same samples.

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