Project description:By the high sensitive cricular RNA micro array, we commpared 10211 circular RNAs abundant in the human gastric cancer tissues and adjacent normal gastric mucosa tissues, and the functional role of differentially expressed circular RNAs were analyzed by bioinformatics. The enrichment results indicated that these circular RNAs may involevd in the occurrence and progression process of gastric cancer.
Project description:Using the highly sensitive cricRNA array, we screened 13617 circRNAs abundant in the human gastric cancer and Adjacent normal gastric mucosa tissues, and the function of differentially expressed circRANs were analyzed by bioinformatics. The enrichment results indicated that these circRNAs perhaps participated in the occurrence and development process of gastric cancer.
Project description:Using the highly sensitive miRCURY LNA™ microRNA array, we screened 3100 microRNAs abundant in the human gastric cancer and Adjacent normal gastric mucosa tissues, and the function of differentially expressed microRNAs were analyzed by bioinformatics. The enrichment results indicated that these microRNAs perhaps participated in the occurrence and development process of gastric cancer.
Project description:Transcriptional profiling of comparing control and GAPLINC knocking-down human gastric cancer cell lines. Goal was to determine the different gene expression between control and GAPLINC knocking-down human gastric cancer cell lines.
Project description:Gastric cancer is the fourth common cancer and second leading cause of cancer related mortality. The survival probability of gastric cancer patients is often less due to the diagnosis at late stage and also due to the heterogenous nature of tumors. Molecular and transcriptome-wide understanding of the dysregulations in gastric tumors from different populations is highly required to delineate the heterogeneity. To delineate the key oncogenic dysregulations in terms of the transcripts, transcription programs and signaling pathways, we performed genome-wide mRNA profiling of human gastric normal and gastric cancer tissues using Affymetrix Human Transcriptome 2.0 arrays.
Project description:We have previously reported human gastrin overexpressing transgenic mice (=INS-GAS mice) and Helicobacter felis (=H.felis) infection synergistically accelerated gastric cancer in mice stomachs. (Wang et al 2000) Using this mouse model, we employed microarray analysis of gene expression profiling to identify gastric cancer-specific genes. Keywords: disease state analysis
Project description:Transcriptional profiling of comparing control and GAPLINC stable knocking-down human gastric cancer cell lines. Goal was to determine the different gene expression between control and GAPLINC stable knocking-down human gastric cancer cell lines. Control and GAPLINC stable knocking-down human gastric cancer cell lines were prepared for RNA extraction and hybridization on Affymetrix microarrays.
Project description:Comparing to matched normal mucosa, WTX was lost in most of human gastric cancers (Zhang et al., 2016). We analyzed the microRNA expression profiling among WTX low human colorectal cancer tissues and matched adjacent WTX high normal colorectal mucosa. The aimed to identify the unique signature of miRNAs which related to WTX loss in human colorectal cancers.