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Mouse peritoneal macrophages treated with three different fatty acids

ABSTRACT: Mouse peritoneal macrophages treated with three different fatty acids

PROVIDER: PRJNA596479 | ENA |

REPOSITORIES: ENA

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Mouse peritoneal macrophages treated with three different fatty acids

Project description:Obesity leads to a state of chronic low-grade inflammation that features accumulation of lipid-laden macrophages in adipose tissue. Here, we determined the role of macrophage lipid droplet accumulation in the development of obesity-induced adipose tissue inflammation, using mice with myeloid-specific deficiency of the lipid-inducible HILPDA protein. HILPDA deficiency markedly reduced intracellular lipid levels and accumulation of fluorescently-labeled fatty acids. Decreased lipid storage in HILPDA-deficient macrophages could be rescued by inhibition of adipose triglyceride lipase (ATGL) and was associated with increased oxidative metabolism. In diet-induced obese mice, HILPDA deficiency did not alter inflammatory and metabolic parameters, despite markedly reducing lipid accumulation in macrophages. Overall, we find that HILPDA is a lipid-induced physiological inhibitor of ATGL-mediated lipolysis in macrophages that uncouples lipid storage in adipose tissue macrophages from inflammation and metabolic dysregulation. Our data question the contribution of lipid droplet accumulation in adipose tissue macrophages in obesity-induced inflammation and metabolic dysregulation.

2019-12-19 | GSE142294 | GEO

RNASeq of Developing Arabidopsis Seeds Producing Hydroxy-Fatty Acids

Project description:Arabidopsis seeds expressing the castor fatty acid hydroxylase accumulate hydroxylated fatty acids up to 17% of total fatty acids in seed triacylglycerols, however total seed oil is also reduced up to 50%. Investigations into the cause of the reduced oil phenotype through in vivo [14C]acteate and [3H]2O metabolic labeling of developing seeds surprisingly revealed that the rate of de novo fatty acid synthesis within the transgenic seeds was approximately half that of control seeds. Addition of castor phospholipid:diacylglycerol acyltransferase (PDAT) increased hydroxylated fatty acid content of the seed oil, increased the rate of fatty acid synthesis, and mostly restored seed oil levels. RNAseq analysis indicated no changes in expression of fatty acid synthesis genes in hydroxylase-expressing plants. Transcript profiles of Arabidopsis developing seeds of three lines, at three stages of development were generated by deep sequencing, in triplicate, using Illumina.

2014-01-10 | E-GEOD-53952 | biostudies-arrayexpress

Expression data from cultured mouse macrophages treated with fatty acids or LPS

Project description:The goal of this study was to compare the transcriptional responses of mouse macrophages treated with unsaturated or saturated fatty acids to macrophages treated with LPS to stimulate classical inflammatory activation. Microarray profiling was performed on total RNA isolated from primary mouse bone marrow-derived macrophages (BMDMs) treated with fatty acids (C18:1 oleic acid or C18:0 stearic acid), BSA vehicle, or LPS at two time points.

2016-03-18 | GSE77104 | GEO

16S rRNA sequencing data of ileal contents samples in goats infusion of three short-chain fatty acids

Project description:Emerging data has highlighted the importance of short-chain fatty acids (SCFAs) on ruminal microbiome and derived metabolism profiling, and ruminal epithelial health and nutritional absorption in ruminants. However, little is known about the roles of SCFAs on ileal microbiome profiles. Here, we combined infusion of three SCFAs, to study their different roles in ileal microbiome succession profiling using a in vivo goat model.

2023-08-14 | GSE240818 | GEO

16S rRNA sequencing data of cecal digesta in goats infusion of three short-chain fatty acids

Project description:Emerging data has highlighted the importance of short-chain fatty acids (SCFAs) on ruminal microbiome and derived metabolism profiling, and ruminal epithelial health and nutritional absorption in ruminants. However, little is known about the roles of SCFAs on hindgut profiles. Here, we firstly combined infusion of three SCFAs, to study their different roles in hindgut microbiome succession and derived metabolism profiling, as well as colonic epithelial transcriptome sequencing patterns using a in vivo goat model. .

2023-08-13 | GSE232036 | GEO

RNA-Seq data of colonic epithelial tissue in goats infusion of three short-chain fatty acids

Project description:Emerging data has highlighted the importance of short-chain fatty acids (SCFAs) on ruminal microbiome and derived metabolism profiling, and ruminal epithelial health and nutritional absorption in ruminants. However, little is known about the roles of SCFAs on hindgut profiles. Here, we firstly combined infusion of three SCFAs, to study their different roles in hindgut microbiome succession and derived metabolism profiling, as well as colonic epithelial transcriptome sequencing patterns using a in vivo goat model.

2023-08-13 | GSE232035 | GEO

Wildtype or Hilpda KO Mouse macrophages treated with fatty acids

Project description:Wildtype or Hilpda KO Mouse macrophages treated with fatty acids

| PRJNA596477 | ENA

RNASeq of Developing Arabidopsis Seeds Producing Hydroxy-Fatty Acids

2014-01-10 | GSE53952 | GEO

Proteome of Pseudomonas aeruginosa growing on different fatty acids versus glucose

Project description:Lung surfactant-derived fatty acids are a primary carbon source for the opportunistic human pathogen, Pseudomonas aeruginosa (PA), in the airways of people with cystic fibrosis. However, the mechanisms underlying the breakdown of these fatty acids by PA, as well as the potential implications of fatty acid degradation on the virulence, remain incompletely elucidated. Here, we compared the proteomes of a Manchester epidemic strain Pa10348 growing on octanoate (C8:0), palmitate (C16:0) and oleate (C18:1) with the proteome of that growing on commonly explored carbon source, glucose.

2025-02-11 | PXD044807 | Pride

Transcription profiling of peripheral blood mononuclear cells in healthy young men 6 hours after intake of either saturated fatty acids or polyunsaturated fatty acids

Project description:Acute effects of different dietary fatty acids on the gene expression profiles of peripheral blood mononuclear cells in healthy young men. A randomized cross-over study.

2009-11-01 | E-MTAB-65 | biostudies-arrayexpress

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