Project description:Bats harbour various viruses without severe symptoms and act as natural reservoirs. This tolerance of bats toward viral infections is assumed to be originated from the uniqueness of their immune system. However, how the innate immune response varies between primates and bats remains unclear. To illuminate differences in innate immune responses among animal species, we performed a comparative single-cell RNA-sequencing analysis on peripheral blood mononuclear cells (PBMCs) from four species including Egyptian fruit bats inoculated with various infectious stimuli.
Project description:Jamaican fruit bats (Artibeus jamaicensis) naturally harbor a wide range of viruses of human relevance. These infections are typically mild in bats, suggesting unique features of their immune system. To better understand the immune response to viral infections in bats, we infected Jamaican fruit bats with the bat-derived influenza A virus H18N11. Using comparative single-cell RNA sequencing, we generated a single-cell atlas of the Jamaican fruit bat intestine and mesentery, the target organs of infection. Gene expression profiling showed that H18N11 infection resulted in a moderate induction of interferon-stimulated genes and transcriptional activation of immune cells. H18N11 infection was prominent in various leukocytes, including macrophages, B cells, and NK/T cells. Confirming these findings, human leukocytes, particularly macrophages, were also susceptible to H18N11, highlighting the zoonotic potential of this virus. Our study provides insight into the virus-host relationship and thus serves as a fundamental resource for further characterization of bat immunology.
2024-05-06 | GSE243982 | GEO
Project description:Viral RNA metagenomics from bats
| PRJNA892907 | ENA
Project description:Viral metagenomics of Swedish bats
| PRJNA823526 | ENA
Project description:EMG produced TPA metagenomics assembly of the PRJNA344863 data set (Viral Metagenomics of fecal samples of fruit bats).
| PRJEB31414 | ENA
Project description:EMG produced TPA metagenomics assembly of the PRJNA344863 data set (Viral Metagenomics of fecal samples of fruit bats).
| PRJEB31341 | ENA
Project description:Viral metagenomics for detection of RVA in bats
| PRJNA562472 | ENA
Project description:Viral metagenomics survey of bats from Saudi Arabia