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Comparative analysis of innate immune responses to viral infection among animals

ABSTRACT: Bats harbour various viruses without severe symptoms and act as natural reservoirs. This tolerance of bats toward viral infections is assumed to be originated from the uniqueness of their immune system. However, how the innate immune response varies between primates and bats remains unclear. To illuminate differences in innate immune responses among animal species, we performed a comparative single-cell RNA-sequencing analysis on peripheral blood mononuclear cells (PBMCs) from four species including Egyptian fruit bats inoculated with various infectious stimuli.

ORGANISM(S): Rousettus aegyptiacus Pan troglodytes Homo sapiens Macaca mulatta

PROVIDER: GSE218199 | GEO | 2023/01/18

REPOSITORIES: GEO

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