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Tip60-mediated acetylation of H2A.Z activates Hoxa9 and Meis1 expression to promote MLL-rearranged acute myeloid leukemia

ABSTRACT: Tip60-mediated acetylation of H2A.Z activates Hoxa9 and Meis1 expression to promote MLL-rearranged acute myeloid leukemia

PROVIDER: PRJNA597547 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10761100_1.fastq.gz	Fastqsanger.gz
	SRR10761100_2.fastq.gz	Fastqsanger.gz
	SRR10761101_1.fastq.gz	Fastqsanger.gz
	SRR10761101_2.fastq.gz	Fastqsanger.gz
	SRR10761103_1.fastq.gz	Fastqsanger.gz

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HOXA9 is required for survival in human MLL rearranged acute leukemias

Project description:Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biological characteristics and often have an unfavorable prognosis. Gene expression analyses demonstrate a distinct profile for MLL-rearranged leukemias with consistent high-level expression of select Homeobox genes including HOXA9. Here, we investigated the effects of HOXA9 suppression in MLL-rearranged and MLL-germline leukemias utilizing RNAi. Gene expression profiling after HOXA9 suppression demonstrated co-downregulation of a program highly expressed in human MLL-AML (this study) and murine MLL-leukemia (Krivtsov et al. 2006) stem cells including HOXA10, MEIS1, PBX3 and MEF2C. Our data indicates an important role for HOXA9 in human MLL-rearranged leukemias, and suggests targeting HOXA9 or downstream programs may be a novel therapeutic option.

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