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Global translation during early development depends on the essential transcription factor PRDM10 [RNA-Seq_2]

ABSTRACT: Global translation during early development depends on the essential transcription factor PRDM10 [RNA-Seq_2]

PROVIDER: PRJNA597726 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10767300.fastq.gz	Fastqsanger.gz
	SRR10767301.fastq.gz	Fastqsanger.gz
	SRR10767302.fastq.gz	Fastqsanger.gz
	SRR10767303.fastq.gz	Fastqsanger.gz
	SRR10767304.fastq.gz	Fastqsanger.gz

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Similar Datasets

Global translation during early development depends on the essential transcription factor PRDM10 [RNA-Seq_2]

Project description:Members of the PR/SET domain-containing (PRDM) family of zinc finger transcriptional regulators play diverse roles in embryonic development and lineage differentiation. PRDM10 is a yet uncharacterized family member, with unknown functions in vivo. Here we report an essential requirement for PRDM10 in the pre-implantation embryo and embryonic stem cells (mESCs), where loss of PRDM10 results in severe cell growth inhibition. Genomic and biochemical analyses reveal that PRDM10 functions as a sequence-specific transcription factor which modulates gene expression by binding to target gene promoters. We identify Eif3b, which encodes a core component of the eukaryotic translation initiation factor 3 (eIF3) complex, as a key downstream target and demonstrate that growth inhibition in PRDM10-deficient mESCs is largely mediated through EIF3B-dependent effects on global translation. This work elucidates the molecular function of PRDM10 in maintaining global translation and establishes its essential role in early embryonic development and mESC homeostasis, offering novel insights into the functional repertoire of PRDMs as well as the transcriptional mechanisms regulating global translation.

2020-05-06 | GSE142600 | GEO

Global translation during early development depends on the essential transcription factor PRDM10

Project description:Global translation during early development depends on the essential transcription factor PRDM10

| PRJNA557181 | ENA

Global translation during early development depends on the essential transcription factor PRDM10 [RNA-seq]

Project description:Global translation during early development depends on the essential transcription factor PRDM10 [RNA-seq]

| PRJNA557184 | ENA

Global translation during early development depends on the essential transcription factor PRDM10 [ChIP-seq]

Project description:Global translation during early development depends on the essential transcription factor PRDM10 [ChIP-seq]

| PRJNA557185 | ENA

Global translation during early development depends on the essential transcription factor PRDM10 [RNA-seq]

2020-05-06 | GSE135021 | GEO

Global translation during early development depends on the essential transcription factor PRDM10 [ChIP-seq]

2020-05-06 | GSE135020 | GEO

Global translation during early development depends on the essential transcription factor PRDM10

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-05-06 | GSE135022 | GEO

EIF4A1 is essential in B cells by promoting activation-induced translation

Project description:EIF4A1 is essential in B cells by promoting activation-induced translation

| PRJNA994938 | ENA

Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation

Project description:Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation

| PRJNA930671 | ENA

VapCs of Mycobacterium tuberculosis Cleave RNAs Essential for Translation

Project description:The major human pathogen Mycobacterium tuberculosis can survive in the host organism for decades without causing symptoms. A large cohort of Toxin-Antitoxin (TA) modules contribute to this persistence. Of these, 48 TA modules belong to the vapBC (virulence associated protein) gene family. VapC toxins are PIN domain endonucleases that, in Enterobacteria, inhibit translation by site-specific cleavage of initiator tRNA. In contrast, VapC20 of M. tuberculosis inhibits translation by site-specific cleavage of the universally conserved Sarcin-Ricin loop (SRL) in 23S rRNA. Here we identify cleavage targets for 12 VapCs from M. tuberculosis by applying UV-crosslinking and deep sequencing. Remarkably, these VapCs are all endoribo-nucleases that cleave RNA targets that are essential for decoding at the ribosomal A-site. Eleven VapCs cleave specific tRNAs while one exhibits SRL cleavage activity. These findings suggest that multiple vapBC modules contribute to the survival of M. tuberculosis in its human host by reducing the level of translation.

2017-08-14 | GSE85905 | GEO

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