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Transcriptional response of mice infected with H9N2 or H7N9

ABSTRACT: Transcriptional response of mice infected with H9N2 or H7N9

PROVIDER: PRJNA598134 | ENA |

REPOSITORIES: ENA

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Transcriptional response of mice infected with H9N2 or H7N9

Project description:Type I interferon (IFN) is the first line of defense against virus infection. By using both in vivo and in vitro influenza infection models, we found that type I IFN-κ, limited the replication of influenza viruses by stimulating a IFNAR-MAPK-cFos-CHD6 axis. Similarly, Zika virus (ZIKV) was also highly sensitive to IFN-κ-mediated suppression. With an IAV infected mouse model, we found that IFN-κ was the earliest responding type I interferon among all known members in mice after H9N2 infection, a low-pathogenic Avian Influenza, whereas this early induction did not occur upon highly pathogenic H7N9 infection. IFN-κ can efficiently contain both low- and high-pathogenic influenza replication in cultured human lung cells, and CHD6 was the major effector responsive molecule for IFN-κ, but not for IFN-α/β. Furthermore, we discovered that both IFNAR1 and IFNAR2 subunits of type I interferon receptor and their downstream axis of p38-cFos are engaged in IFN-κ signaling cascade to acti vate CHD6, which didn`t require STAT1 activity. In addition, we showed that the pre-treatment with IFN-κ before IAV challenge protected mice from high mortality. Altogether, our study identified an IFN-κ-specific pathway that suppressed influenza A virus in vitro and in vivo. Thus, IFN-κ may have potential as a new prevention and treatment agents against emerging viruses

2020-04-09 | GSE142707 | GEO

Homo sapiens strain:H1N1/H7N9/H9N2 | isolate:H1N1/H7N9/H9N2 | breed:human | cultivar:iav

Project description:A549 infected with H1N1/H7N9/H9N2 circRNAs Raw sequence reads

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Homo sapiens strain:H1N1/H7N9/H9N2 | isolate:H1N1/H7N9/H9N2 | breed:human | cultivar:iav

Project description:A549 infected with PBS/H1N1/H7N9/H9N2 circRNAs Raw sequence reads

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circRNAs of A549 infected with H1N1/H7N9/H9N2 or PBS

Project description:circRNAs of A549 infected with H1N1/H7N9/H9N2 or PBS Raw sequence reads

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Differential expression data of BMDMs of mice infected with avian influenza influenza A (H7N9) viruses

Project description:To clarify the underlying mechanism that regulates the response of iron metabolism to influenza A virus infection, we analyzed gene expression profiles in mouse, bone marrow-derived macrophages (BMDMs) infected with H7N9 virus. In addition, We also analysed the chemokine, inflammation, innate-immunity, lipid-metabolism, transcription mRNA level by micrroarray. So, we gain the global transcriptional response in the BMDMs of mice infected with H7N9 virus.

2018-04-13 | GSE112964 | GEO

Mouse lung tissue transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses [microRNA]

Project description:The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in mouse lung infected with WT A/Anhui/1/2013 (H7N9; 'AH1'), AH - NS1-103F/106M, and AH1 - 691 (ferret adapted virus). Groups of 22-week-old C57BL/6 mice were infected with the H7N9 Influenza WT A/Anhui/1/2013 (H7N9; 'AH1'), AH - NS1-103F/106M, and AH1 - 691 (ferret adapted virus). Infections were done at 10^4 PFU or time-matched mock infected. Time points were 1, 2, 4 and 7 d.p.i. There were 5 animals/dose/time point. Lung samples were collected for virus load, transcriptional and proteomics analysis. Weight loss and animal survival were also monitored.

2015-05-16 | E-GEOD-68946 | biostudies-arrayexpress

Mouse lung tissue transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses [mRNA]

2015-05-16 | E-GEOD-68945 | biostudies-arrayexpress

Transcriptional profile from peripheral blood in patients infected with avian influenza H7N9 virus

Project description:Avian influenza A (H7N9) viruses have emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profile from peripheral blood has been shown to reflect host responses against a specific respiratory pathogen and can be used to understand the disease. Methods: We correlated the clinical data and blood transcriptomic profile of patients with avian influenza A (H7N9) disease and determined the biological significance of the infection from the analysis.

2018-05-31 | GSE114466 | GEO

Gene expression analysis of chicken dendritic cells (DCs) in response to H9N2 avian influenza virus infection

Project description:We analyze the differentially expressed genes (DEGs) at the transcriptome level in chicken DCs infected with H9N2 influenza virus compared to mock infection by high-throughput RNA-sequencing technology, and found that H9N2 influenza virus infection induced a strong innate immune response in chicken DCs, but impaired the antigen-processing and –presenting capacity of this cell,

2020-02-26 | GSE117163 | GEO

Mouse lung tissue transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses [microRNA]

2015-05-16 | GSE68946 | GEO