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Transcriptomic signatures and chromatin structure in adipocytes isolated from premenauposal women subcutaneous fat [ATAC-seq]

ABSTRACT: Transcriptomic signatures and chromatin structure in adipocytes isolated from premenauposal women subcutaneous fat [ATAC-seq]

PROVIDER: PRJNA600519 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10870645.fastq.gz	Fastqsanger.gz
	SRR10870646.fastq.gz	Fastqsanger.gz
	SRR10870647.fastq.gz	Fastqsanger.gz
	SRR10870648.fastq.gz	Fastqsanger.gz
	SRR10870649.fastq.gz	Fastqsanger.gz

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Transcriptomic signatures and chromatin structure in adipocytes isolated from premenauposal women subcutaneous fat

Project description:Transcriptomic signatures and chromatin structure in adipocytes isolated from premenauposal women subcutaneous fat

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Transcriptomic signatures and chromatin structure in adipocytes isolated from premenauposal women subcutaneous fat [ATAC-seq]

Project description:Our data showed that lipid and glucose metabolic pathways genes were expressed at higher levels in gluteofemoral adipocyte fraction in pears, while genes associated with inflammation were higher in both abdominal and gluteofemoral apple adipocyte fraction. Gluteofemoral adipocyte chromatin from pear-shaped women contained a significantly higher number of differentially open ATAC-seq peaks relative to chromatin from the apple-shaped gluteofemoral adipocytes. In contrast, abdominal adipocyte chromatin openness showed few differences between apple and pear-shaped women. We revealed a correlation between gene transcription and open chromatin at the proximity of the TSS of some of the differentially expressed genes.

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Transcriptomic signatures and chromatin structure in adipocytes isolated from premenauposal women subcutaneous fat [RNA-seq]

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Transcriptomic signatures and chromatin structure in adipocytes isolated from premenauposal women subcutaneous fat [RNA-seq]

Project description:Transcriptomic signatures and chromatin structure in adipocytes isolated from premenauposal women subcutaneous fat [RNA-seq]

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Project description:Adipocytes isolated from lean and obese postmenopausal women with no significant differences in metabolic syndrome parameters demonstrate changes in multiple inflammatory, metabolic and structural gene families. Purified adipocyte samples were isolated from subcutaneous adipose tissue surgical biopsies of 7 obese (BMI>30) and 7 lean (BMI<25) postmenoposal women and gene expression was quantified with Agilent-014850, 4X44K human whole genome platform arrays (GPL6480)

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Transcriptomic signatures and chromatin structure in adipocytes isolated from premenauposal women subcutaneous fat

Project description:This SuperSeries is composed of the SubSeries listed below.

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Expression data from human subcutaneous adipocytes

Project description:An Affimetrix GeneChip Human Genome U133 Plus 2.0 Array was used to study the effect of oleoylethnolamide on gene expression. The addition of 0.01 mM oleoylethanolamide (OEA) to human subcutaneous adipocytes significantly affected the expression of 1013 genes, with 556 being up-regulated and 457 being down-regulated. Human subcutaneous adipocytes were incubated with oleoylethanolamide (0.01 mM). After 24 hr, the gene expression in human subcutanous adipocytes was analyzed using Affymetrix microarrays.

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