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Muscle injury causes long-term changes in stem cell DNA methylation [RRBS]

ABSTRACT: Muscle injury causes long-term changes in stem cell DNA methylation [RRBS]

PROVIDER: PRJNA601988 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10910728_1.fastq.gz	Fastqsanger.gz
	SRR10910728_2.fastq.gz	Fastqsanger.gz
	SRR10910729_1.fastq.gz	Fastqsanger.gz
	SRR10910729_2.fastq.gz	Fastqsanger.gz
	SRR10910730_1.fastq.gz	Fastqsanger.gz

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Muscle injury causes long-term changes in stem cell DNA methylation [RRBS]

Project description:Injury to muscle brings about the activation of stem cells, which then generate new myocytes to replace the damaged tissue. We now demonstrate that this activation causes a dramatic change in the stem cell methylation pattern that prepares them epigenetically for terminal myocyte differentiation. These demethylation and de novo methylation events occur at regulatory elements associated with genes involved in myogenesis. Local injury of one muscle brings about an almost identical epigenetic change in satellite cells from other muscles in the body, as well. Furthermore, this same methylation state is also generated in muscle stem cells of female animals following full-term pregnancy, even in the absence of any injury. In all of these cases, which appear to be mediated by circulating factors, the new methylation profile is then stably maintained in resident muscle stem cells and thus represents a molecular memory of previous physiological events that is probably programmed to provide a mechanism for adapting to the environment.

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Project description:Muscle injury causes gene expression changes that are related to long-term changes in stem cell DNA methylation [RNA-Seq]

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Project description:Injury to muscle brings about the activation of stem cells, which then generate new myocytes to replace damaged tissue. We demonstrate that this activation is accompanied by a dramatic change in the stem-cell methylation pattern that prepares them epigenetically for terminal myocyte differentiation. These de- and de novo methylation events occur at regulatory elements associated with genes involved in myogenesis and are necessary for activation and regeneration. Local injury of one muscle elicits an almost identical epigenetic change in satellite cells from other muscles in the body, in a process mediated by circulating factors. Furthermore, this same methylation state is also generated in muscle stem cells (MuSCs) of female animals following pregnancy, even in the absence of any injury. Unlike the activation-induced expression changes, which are transient, the induced methylation profile is stably maintained in resident MuSCs and thus represents a molecular memory of previous physiological events that is probably programmed to provide a mechanism for long-term adaptation.

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