Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mechanisms of immune evasion in P. falciparum malaria revealed by integrative gene expression profiling

ABSTRACT: Mechanisms of immune evasion in P. falciparum malaria revealed by integrative gene expression profiling

PROVIDER: PRJNA603773 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10982000.fastq.gz	Fastqsanger.gz
	SRR10985300_1.fastq.gz	Fastqsanger.gz
	SRR10985300_2.fastq.gz	Fastqsanger.gz
	SRR10982001.fastq.gz	Fastqsanger.gz
	SRR10985301_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 223

Similar Datasets

Mechanisms of immune evasion in P. falciparum malaria revealed by integrative gene expression profiling [miRNA]

Project description:Mechanisms of immune evasion in P. falciparum malaria revealed by integrative gene expression profiling [miRNA]

| PRJNA603577 | ENA

Mechanisms of immune evasion in P. falciparum malaria revealed by integrative gene expression profiling [RNA-seq]

Project description:Mechanisms of immune evasion in P. falciparum malaria revealed by integrative gene expression profiling [RNA-seq]

| PRJNA603772 | ENA

Mechanisms of immune evasion in P. falciparum malaria revealed by integrative gene expression profiling [miRNA]

Project description:We performed a genome-wide profiling of miRNAs and mRNA, DNA sequencing of human whole blood sample to identify miRNAs responsive to P.falciparum (P.f) infection and/or associated with parasite load. We identified a set of 72 miRNAs that are positively or negatively associated with parasitemia. We also performed expression quantitative trait loci of miRNAs(miR-eQTL) of P.f infected individuals. The miR-eQTL dataset allowed us to determine relevant genetic variant responsible for miRNAs expression differences between P.f infected individuals and find novel malaria-associated miRNAs

2020-09-05 | GSE144413 | GEO

Mechanisms of immune evasion in P. falciparum malaria revealed by integrative gene expression profiling [RNA-seq]

2020-09-05 | GSE144476 | GEO

Mechanisms of immune evasion in P. falciparum malaria revealed by integrative gene expression profiling

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-09-05 | GSE144486 | GEO

Replication origin mapping in the malaria parasite P. falciparum

Project description:Replication origin mapping in the malaria parasite Plasmodium falciparum

2022-08-04 | GSE210010 | GEO

Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria.

Project description:The mechanisms behind the ability of Plasmodium falciparum to evade host immune system are poorly understood and are a major roadblock in achieving malaria elimination. Here, we use integrative genomic profiling and a longitudinal pediatric cohort in Burkina Faso to demonstrate the role of post-transcriptional regulation in host immune response in malaria. We report a strong signature of miRNA expression differentiation associated with P. falciparum infection (127 out of 320 miRNAs, B-H FDR 5%) and parasitemia (72 miRNAs, B-H FDR 5%). Integrative miRNA-mRNA analysis implicates several infection-responsive miRNAs (e.g., miR-16-5p, miR-15a-5p and miR-181c-5p) promoting lymphocyte cell death. miRNA cis-eQTL analysis using whole-genome sequencing data identified 1,376 genetic variants associated with the expression of 34 miRNAs (B-H FDR 5%). We report a protective effect of rs114136945 minor allele on parasitemia mediated through miR-598-3p expression. These results highlight the impact of post-transcriptional regulation, immune cell death processes and host genetic regulatory control in malaria.

| S-EPMC7547729 | biostudies-literature

Capturing the dynamic RNA landscape of the malaria parasite P. falciparum

Project description:To date, total mRNA analysis throughout intraerythrocytic development of the malaria parasite, Plasmodium falciparum, has only revealed abundance profiles of each gene at a given time. Here, we establish a new methodology in Plasmodium falciparum that enables biosynthetic labeleing and capture of sub-population mRNA. As a proof of principle for this novel method, we examine the mRNA dynamics of early gametocyte commitment.

2015-09-04 | GSE72695 | GEO

Comparative gene expression analysis of chloroquine sensitive and resistant strains of Plasmodium falciparum using RNA-Seq

Project description:Drug resistance in Plasmodium falciparum is an important public health burden since it reverses the malaria control achieved so far. Understanding the mechanism of drug resistance will help us to develop novel drug/vaccine targets for malaria treatment. In the present study, we have used the whole transcriptome sequencing to characterize the transcriptional difference between chloroquine sensitive and resistant P. falciparum strains (3D7 and Dd2). The differential gene expression between these strains was analyzed to understand their phenotypic properties like drug sensitivity, immune evasion and pathways involved.

2016-05-06 | GSE77499 | GEO

Whole Blood MicroRNA Biomarkers for Blood-stage of Imported Falciparum Malaria through Integrated mRNA and miRNA Expression Profiling [miRNA]

Project description:human blood mRNA and miRNA expression profile in imported falciparum malaria vs. health.

2019-08-31 | GSE119151 | GEO