Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Exposure to Air pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics

ABSTRACT: Exposure to Air pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics

PROVIDER: PRJNA607560 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11114667_1.fastq.gz	Fastqsanger.gz
	SRR11114667_2.fastq.gz	Fastqsanger.gz
	SRR11114668_1.fastq.gz	Fastqsanger.gz
	SRR11114668_2.fastq.gz	Fastqsanger.gz
	SRR11114669_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Exposure to Air pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics

Project description:Empirical evidence from both animals and humans suggest that PM2.5 (particulate matter < 2.5μm) exposure accelerates a variety of non-communicable diseases (NCDs) including Type 2 diabetes. We investigated whether chronic exposure to ambient air pollution (PM2.5), disrupts circadian rhythm to facilitate metabolic insulin resistance and compared the impact of inhaled ambient PM2.5 alone or in combination with continuous light exposure (LL). Exposure to PM2.5 induced peripheral IR, disrupted circadian steroid release, reduced peak oxygen consumption and altered brown adipose 18Ffluorodeoxyglucose uptake on PET imaging. These findings were identical to that seen with LL with no additive interaction between PM2.5 and LL. Transcriptome profiles in the liver revealed a number of differentially expressed circadian genes Bmal1 (Arntl/Npas2), Period (Per) and Cryptochrome (Cry) in response to PM2.5. Alteration in chromatin accessibility in circadian targets was observed with PM2.5 by Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) while chromatin immunoprecipitation (ChIP) analysis, showed a marked difference in promoter occupancy by p300. Our data suggest a previously unrecognized role of particulate air pollution in promoting circadian disruption and metabolic dysfunction through epigenetic regulation of multiple circadian targets

2020-12-01 | GSE145566 | GEO

Circadian rhythm in NIH3T3 cells

2015-12-31 | GSE66243 | GEO

Circadian rhythm in NIH3T3 cells

Project description:Identification of cyclical expressed coding and non-coding genes during the circadian rhythm in NIH3T3 cells. NIH3T3 cells were synchronized for their circadian rhythm and RNA sequencing were performed at several time points along the rhythm. This data was used to identify cyclical expressed genes as well as long intergenic non-coding RNAs. NIH3T3 cells were synchronized with 100 nM Dexamethasone for 2 hours, then medium was changed to normal culture medium (0h). Every 4 hours cells were harvested, RNA isolated and RNAseq performed.

2015-12-31 | E-GEOD-66243 | biostudies-arrayexpress

Circadian rhythm in clock mutants

Project description:Circadian rhythm in clock mutants

| PRJNA93919 | ENA

Circadian rhythm in Clock mutant and Cry deficient mice

Project description:Molecular analysis of circadian rhythm in mice. Liver tissue of wildtype, Clock mutant and Cry deficient C57BL/6 8- to 10-week-old male mice examined. Keywords = circadian rhythm Keywords: other

2003-11-08 | GSE454 | GEO

Effect of d-alanine on circadian rhythm

Project description:To investigate the effect of d-ala on circadian rhythm.

2023-12-28 | GSE227755 | GEO

Differential gene expression between individuals exposed to different levels of air pollution

Project description:Comparison of genome-wide gene expression between humans living in areas of high levels of air pollution and less polluted areas. Keywords: Comparison of genome-wide gene expression between different conditions

2008-04-17 | GSE7543 | GEO

SINERGIA-Phyllosphere bacteria and air pollution

Project description:SINERGIA-Phyllosphere bacteria and air pollution

| PRJEB28871 | ENA

DNA Methylomic Differences in Adults Asthmatics of Varying Severity and Exposure to Air Pollution

Project description:Rationale: DNA methylation plays a critical role in asthma development, but differences in DNA methylation associated with asthma severity, especially among adults, are less well-defined. Changes in DNA methylation are influenced by exposure to air pollution, which is a risk factor for asthma exacerbation and severity. Here, we examined how DNA methylomic patterns in adult asthmatics differ by asthma severity and exposure to different components of air pollution. Methods: Peripheral blood CD3+ T cells from adult asthmatics in Beijing, China were serially collected from 37 patients (130 samples total) and analyzed for global DNA methylation using the Illumina MethylationEPIC Array. Measurements and Main Results: Significant differences in DNA methylation were noted among subjects with different degrees of asthma severity, as measured by fraction of exhaled nitric oxide, forced expiratory volume, and asthma control test scores. Differences in DNA methylation were annotated to genes that were enriched in pathways related to asthma or T cell function, and included gene ontology categories related to cellular adhesion, developmental pathways, and calcium signaling. Notable genes that were differentially methylated based on asthma severity included RUNX3, several members of the HLA family, PDGFRA, CDH1, CAV1, and NOTCH4. Differences in DNA methylation also varied by exposure to ambient air pollution, with different components of pollution effecting methylation of different groups of genes. Conclusion: These findings demonstrate how adult asthmatics possess widespread differences in the DNA methylation that associated with varying asthma severity and how air pollution might contribute to more severe asthma via changes in DNA methylation.

2024-07-31 | GSE226257 | GEO

CIRCADIAN RHYTHM REPROGRAMMING DURING LUNG INFLAMMATION

Project description:CIRCADIAN RHYTHM REPROGRAMMING DURING LUNG INFLAMMATION

| PRJNA255326 | ENA