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RFX8-mediated Transcriptional Activation of DDX24 Promotes Hepatocellular Carcinoma Via LAMB1/SRC Signaling [RIP-seq]

ABSTRACT: RFX8-mediated Transcriptional Activation of DDX24 Promotes Hepatocellular Carcinoma Via LAMB1/SRC Signaling [RIP-seq]

PROVIDER: PRJNA607779 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11123270_1.fastq.gz	Fastqsanger.gz
	SRR11123270_2.fastq.gz	Fastqsanger.gz
	SRR11123271_1.fastq.gz	Fastqsanger.gz
	SRR11123271_2.fastq.gz	Fastqsanger.gz
	SRR11123272_1.fastq.gz	Fastqsanger.gz

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RFX8-mediated Transcriptional Activation of DDX24 Promotes Hepatocellular Carcinoma Via LAMB1/SRC Signaling [RIP-seq]

Project description:Hepatocellular carcinoma (HCC) is not only the fifth most prevalent cancer, presenting a major global health problem, but also among the leading causes of cancer-related deaths worldwide as its therapeutic targets are limited. To identify novel therapeutic targets, elucidate its oncogenic activities and molecular mechanism in HCC is urgent. We used R language edgeR package screened the expression profiles of 374 tissue samples obtained from patients with HCC and 50 samples of normal liver tissues obtained from The Cancer Genome Atlas (TCGA) database. Focusing on DDX24, we explored the functional effect and clinical significance of DDX24 in HCC. We provided evidence that DDX24 was a potential pro-tumorigenic gene in HCC. DDX24 knockdown inhibited HCC cell growth in vitro and in vivo. Mechanistically, RFX8 was proved to be DDX24 promoter-binding protein that transcriptionally upregulated DDX24 expression. Furthermore, we found that DDX24 bound to, and increased the stability of, LAMB1 mRNA by RNA immunoprecipitation (RIP) sequencing and RNA sequencing. Survival analysis indicated that HCC patients with high DDX24, RFX8, or LAMB1 expression exhibited poor prognosis. Our results demonstrated that DDX24 promoted HCC via RFX8/DDX24/LAMB1 pathway, which can be exploited as potential therapeutic target against HCC.

2020-02-21 | GSE145632 | GEO

RFX8-mediated Transcriptional Activation of DDX24 Promotes Hepatocellular Carcinoma Via LAMB1/SRC Signaling [RNA-seq]

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RFX8-mediated Transcriptional Activation of DDX24 Promotes Hepatocellular Carcinoma Via LAMB1/SRC Signaling

Project description:RFX8-mediated Transcriptional Activation of DDX24 Promotes Hepatocellular Carcinoma Via LAMB1/SRC Signaling

| PRJNA607774 | ENA

i.e. RFX8 mediates DDX24 transcription in human hepatocellular carcinoma

Project description:Accumulating evidence suggests that DEAD-box proteins are essential in RNA metabolism and play pivotal roles in cancer progression. However, the mechanisms underlying how DDX24 drives hepatocellular carcinoma (HCC) remain largely unknown. In this study, we demonstrated that DDX24 was an oncogene and identified RFX8 as a DDX24 promoter-binding protein that transcriptionally upregulated DDX24 expression.

2021-01-29 | PXD022650 | Pride

DDX24 promotes hepatocellular carcinoma progression via NCL dependent signaling pathway

Project description:Accumulating evidence suggests that DEAD-box proteins are essential in RNA metabolism and play pivotal roles in cancer progression. However, the mechanisms underlying how DDX24 drives hepatocellular carcinoma (HCC) remain largely unknown. In this study, we demonstrated that DDX24 was an oncogene and identified DDX24 promoted HCC development via interacting with NCL.

2021-01-29 | PXD023321 | Pride

RFX8-mediated Transcriptional Activation of DDX24 Promotes Hepatocellular Carcinoma Via LAMB1/SRC Signaling [RNA-seq]

Project description:RFX8-mediated Transcriptional Activation of DDX24 Promotes Hepatocellular Carcinoma Via LAMB1/SRC Signaling [RNA-seq]

| PRJNA607778 | ENA

RFX8-mediated Transcriptional Activation of DDX24 Promotes Hepatocellular Carcinoma Via LAMB1/SRC Signaling

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-02-21 | GSE145636 | GEO

RNA-seq after siRNA targeting DDX24 applied to iHUVECs cell lines

Project description:DDX24 Mutations Associated with Vascular Malformations

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DDX24 Promotes Lymphangiogenesis and Lymph Node Metastasis via AGRN Production in Cervical Squamous Cell Carcinoma

Project description:To investigate the factor produced by CSCC cells to facilitate lymphangiogenesis, we analyzed the transcriptomics of CSCC cells upon DDX24 has been knocked down by siRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different cell lines.

2024-07-17 | GSE229910 | GEO

DDX24 in Vascular Smooth Muscle Cells Is Essential for Vascular Development via Direct Association with FANCA mRNA

Project description:To investigate the role of DDX24 in vascular smooth muscle cells, RNA-seq of HASMC with DDX24 knockdown was performed.

2024-05-31 | GSE232777 | GEO