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Telomerase reverse transcriptase promotes stem cell competition through MYC

ABSTRACT: Telomerase reverse transcriptase promotes stem cell competition through MYC

PROVIDER: PRJNA607813 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11176200_1.fastq.gz	Fastqsanger.gz
	SRR11176200_2.fastq.gz	Fastqsanger.gz
	SRR11176201_1.fastq.gz	Fastqsanger.gz
	SRR11176201_2.fastq.gz	Fastqsanger.gz
	SRR11176202_1.fastq.gz	Fastqsanger.gz

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Telomerase reverse transcriptase promotes stem cell competition through MYC

Project description:This SuperSeries is composed of the SubSeries listed below.

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MST-312: a telomerase inhibitor effectively blocking MYC oncogenic functions [array]

Project description:Reactivation of the telomerase reverse transcriptase subunit, TERT, is linked to tumourigenesis due to well-documented telomere-dependent and independent functions. The aim of this study was to investigate the effect of the telomerase inhibitor, MST-312, on TERT functions, focusing in particular, on its effects on MYC stabilty and MYC-regulated pathways, in order to assess its potential as a therapeutic agent. We demonstrate that MST-312 reduces MYC levels in cancer cells, leading to reduced MYC levels on chromatin, and subsequently affecting the MYC-regulated transcriptional program. As a result, MST-312 treatment increases the survival of lymphoma-bearing mice. Mechanistically, MST-312 affects the conformation of TERT, leading to TERT/Terc dissociation, and the subsequent loss of both its telomere-dependent and independent functions. Based on the presented data, we conclude that MST-312 treatment is a promising therapeutic strategy, in particular, in MYC-driven tumorus.

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