Project description:CNE-2Z cells transfected with an empty vector or a TIPE1 lentiviral vector were collected for gene expression detection. Some of them, for instance, the expression of the downstream mTOR signaling pathway was dramatically upregulated. We used microarrays to detail the gene expression after transfection with TIPE1 and identified distinct classes of changed genes during this process. We used microarrays to detail the gene expression after transfected with TIPE1 and identified distinct classes of changed genes during this process.
2020-03-21 | GSE147252 | GEO
Project description:ALA improves PCOS by regulating lipid metabolism and restoring gut microecology.
Project description:Ramulus Mori (Sangzhi) alkaloids (SZ-A) improves lipid metabolism and adipose tissue inflammation in HFD-induced obese mice.This study compares transcriptome profiling (RNA-seq) in the epididymal adipose tissue of normal chow, high-fat diet (HFD) control and SZ-A-treated HFD mice to verify the regulatory mechanisms of SZ-A. These results demonstrated that SZ-A regulates lipid metabolism and inflammation.
Project description:HeLa cells transfected with an empty vector or a TIPE1 lentiviral vector were collected for gene expression detection. Some of them, for instance, the expression of genes induced by p53 was dramatically decreased. We used microarrays to detail the gene expression after transfection with TIPE1 and identified distinct classes of changed genes during this process.
Project description:Macrophages perform key and distinct functions in maintaining tissue homeostasis through finely tuning their polarization state.Here, we found that tumor necrosis factor-α-induced protein 8-like 1 (TIPE1) was highly expressed in macrophages and Tipe1 depletion impeded M2 polarization of macrophages. The goals of this study are to compare BMDMs from LyzM-Cre; Tipe1f/f or Tipe1f/f mice to have a further view of the potential difference.
2021-09-05 | GSE183208 | GEO
Project description:L. japonica improves lipid metabolism and inflammation in high-fat diet fed mice
