Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

H2A.Z ChIP seq datasets of Trypanosoma brucei in WT cells and 2T1 cells, which were depleted of HAT1 or HAT2 over a time period up to 72 h

ABSTRACT: H2A.Z ChIP seq datasets of Trypanosoma brucei in WT cells and 2T1 cells, which were depleted of HAT1 or HAT2 over a time period up to 72 h

PROVIDER: PRJNA608430 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11165200_1.fastq.gz	Fastqsanger.gz
	SRR11165200_2.fastq.gz	Fastqsanger.gz
	SRR11165201_1.fastq.gz	Fastqsanger.gz
	SRR11165201_2.fastq.gz	Fastqsanger.gz
	SRR11165202_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 84

Similar Datasets

H2A.Z ChIP seq datasets of Trypanosoma brucei in WT cells and 2T1 cells, which were depleted of HAT1 or HAT2 over a time period up to 72 h

Project description:Analysis of the genome-wide distribution of the histone variant H2A.Z following depletion of HAT1 or HAT2 over a time period up to 72 h and in WT cells

2020-02-24 | GSE145810 | GEO

TY1-RPB9 ChIP seq datasets of Trypanosoma brucei in 2T1 cells, which were depleted of HAT1 or HAT2 over a time period up to 48 h

Project description:Analysis of the genome-wide distribution of RNA Pol II subunit RPB9, endogenously tagged with 2 x TY1, following depletion of HAT1 or HAT2 over a time period up to 48 h and in WT cells

2020-02-22 | GSE145707 | GEO

Hat1 WT and Hat1 KO MEFs analyzed to identify sites of acetylation that are dependent on Hat1

Project description:Hat1 WT and Hat1 KO MEFs were grown on both galactose and glucose. Abundance of acetylated peptides was compared between the samples.

2020-02-28 | PXD017362 | Pride

RNA-seq datasets of Trypanosoma brucei WT cells and 2T1 cells, which were depleted of HAT1 or HAT2 for 48 h

Project description:To analyze the effect of HAT1 or HAT2 depletion on transcript levels, we performed RNA-seq analyses comparing the transcript levels after 48 h of HAT1 or HAT2 depletion to WT levels.

2020-02-21 | GSE145622 | GEO

Diurnal Regulation of Gene Expression in Leaves and Immature Ears Over a 72-Hour Period

Project description:This SuperSeries is composed of the following subset Series: GSE23916: Diurnal Regulation of Gene Expression in Immature Ear Over a 72-Hour Period GSE23917: Diurnal Regulation of Gene Expression in Leaves Over a 72-Hour Period Refer to individual Series

2010-09-02 | E-GEOD-23918 | biostudies-arrayexpress

TY1-RPB9 ChIP seq datasets of Trypanosoma brucei in 2T1 cells, which were depleted of HAT1 or HAT2 over a time period up to 48 h

Project description:TY1-RPB9 ChIP seq datasets of Trypanosoma brucei in 2T1 cells, which were depleted of HAT1 or HAT2 over a time period up to 48 h

| PRJNA607985 | ENA

HAT1 coordinates histone production and acetylation via H4 promoter binding

Project description:The energetic costs of duplicating chromatin are large and therefore likely depend on nutrient sensing checkpoints and metabolic inputs. By studying chromatin modifiers regulated by epithelial growth factor, we identified histone acetyltransferase 1 (HAT1) as an induced gene that enhances proliferation through coordinating histone production, acetylation and glucose metabolism. In addition to its canonical role as a cytoplasmic histone H4 acetyltransferase, we isolated a HAT1-containing complex bound specifically at promoters of H4 genes. HAT1-dependent transcription of H4 genes required an acetate-sensitive promoter element. HAT1 expression was critical for S-phase progression and maintenance of H3 lysine 9 acetylation at proliferation-associated genes, including histone genes. Therefore, these data describe a feed-forward circuit whereby HAT1 captures acetyl-groups on nascent histones and drives H4 production by chromatin binding to support chromatin replication and acetylation. These findings have important implications for human disease, since high HAT1 levels associate with poor outcomes across multiple cancer types.

2019-07-02 | GSE117472 | GEO

Transcription factor AmyR and Molecular brake Hat1 modulate amylase gene expression in Penicillium oxalicum

Project description:The goals of this study are to compare different gene expressions for Penicillium oxalicum wild type strain (WT), Hat1 deletion strain (ΔHat1) and AmyR deletion strain (ΔAmyR) in 2% starch as carbon sources. The correlation analysis results between the various samples showed that the gene expression levels of the wild strain and the ΔHat1 strain were significantly different, and the gene expression levels between ΔAmyR and the wild strain were also significantly different. The deletion of Hat1 significantly up-regulates the expression levels of amylase genes of Penicillium oxalicum, and the absence of AmyR can significantly down-regulate the expression level of amylase genes genes, indicating that Hat1 and AmyR can cause a difference in amylase synthesis by affecting the expression of amylase genes. The information provided by this study indicates that Hat1 and AmyR functions are necessary for the amylase activity of Penicillium oxalicum.

2021-05-28 | GSE175682 | GEO

Expression data from H2A.Z-1 and H2A.Z-2 double KO cells

Project description:The histone variant H2A.Z is evolutionarily conserved from yeast to vertebrates. H2A.Z regulates gene expression when localized to promoter region. Recently, we identified two genes encoding H2A.Z, H2A.Z-1 and H2A.Z-2 in vertebrate genome. However, it is not clear that both H2A.Z-1 and H2A.Z-2 were required for the function of H2A.Z in gene regulation. To address this issue, we generated the H2A.Z-1 and H2A.Z-2 double knock out (KO) cells in chicken DT40 cells. The expression pattern of H2A.Z-1 and H2A.Z-2 double KO cells was compared with WT cells to characterize the genes regulated by H2A.Z-1 and H2A.Z-2. We used microarrays to analysis the alternation of gene expression between WT and H2A.Z double KO cells and identify classes of up or down regulated gene by H2A.Z-1 and H2A.Z-2. In H2A.Z-1 and H2A.Z-2 double KO cells, H2A.Z-2 is knocked out constitutively, but H2A.Z-1 conditionally by tetracycline. The expression of H2A.Z-1 transgene is suppressed completely when H2A.Z-1 and H2A.Z-2 double KO cells culture with tetracycline for three days. For this reason, we prepared the total RNA of WT cells and H2A.Z-1and H2A.Z-2 double KO cells treated with tetracycline for three days and hybridization on Affymetrix microarrays.

2015-11-04 | E-GEOD-35430 | biostudies-arrayexpress

Mammalian PERIOD2 regulates H2A.Z incorporation into chromatin to orchestrate circadian negative feedback [RNA-Seq]

Project description:We report the interdependance of PERIOD and H2A.Z to orchestrated the circadian negative feedback. H2A.Z is required for the circadian rhythm, it allows the binding of Bmal1 and PERIOD2 to the chromatin. And reciprocally, PERIOD2 aid H2A.Z deposition by interacting with the specific chaperone YL1.

2022-02-17 | GSE153937 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data