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Hat1 WT and Hat1 KO MEFs analyzed to identify sites of acetylation that are dependent on Hat1

ABSTRACT: Hat1 WT and Hat1 KO MEFs were grown on both galactose and glucose. Abundance of acetylated peptides was compared between the samples.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Fibroblast

SUBMITTER: Mark Parthun

LAB HEAD: Mark Robert Parthun

PROVIDER: PXD017362 | Pride | 2020-02-28

REPOSITORIES: Pride

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			Action	DRS
	171031_26199_AS_L.raw	Raw
	171031_26200_AS_L.raw	Raw
	171031_26201_AS_L.raw	Raw
	171031_26202_AS_L.raw	Raw
	171031_26203_AS_L.raw	Raw

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Publications

Hat1-Dependent Lysine Acetylation Targets Diverse Cellular Functions.

Agudelo Garcia Paula A PA Nagarajan Prabakaran P Parthun Mark R MR

Journal of proteome research 20200304 4

Lysine acetylation has emerged as one of the most important post-translational modifications, regulating different biological processes. However, its regulation by lysine acetyltransferases is still unclear in most cases. Hat1 is a lysine acetyltransferase originally identified based on its ability to acetylate histones. Using an unbiased proteomics approach, we have determined how loss of Hat1 affects the mammalian acetylome. Hat1<sup>+/+</sup> and Hat1<sup>-/-</sup> mouse embryonic fibroblast ...[more]

PMID: 32081014

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