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ScRNA-seq of E15.5 epicardium and epicardium-derived cells

ABSTRACT: scRNA-seq of E15.5 epicardium and epicardium-derived cells

PROVIDER: PRJNA608475 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11173500.fastq.gz	Fastqsanger.gz
	SRR11173600.fastq.gz	Fastqsanger.gz
	SRR11173501.fastq.gz	Fastqsanger.gz
	SRR11173601.fastq.gz	Fastqsanger.gz
	SRR11173502.fastq.gz	Fastqsanger.gz

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scRNA-seq of E15.5 epicardium and epicardium-derived cells

Project description:The embryonic epicardium provides a source of multipotent progenitors for cardiac lineages, including pericytes, fibroblasts and smooth muscle cells. However, it remains unclear if the epicardium comprises of heterogeneous progenitors or if epicardial cells are multipotent. Using scRNA-seq, we analysed the expression profile of epicardial and epicardial-derived cells at E15.5 and found no evidence of discrete epicardial sub-compartments. Our findings also support the notion that epicardial fate is specified after epithelial-mesenchymal transition, not pre-determined.

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