Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-Seq during tumor cell plasticity and Platr18 overexpression/silencing

ABSTRACT: RNA-Seq during tumor cell plasticity and Platr18 overexpression/silencing

PROVIDER: PRJNA609944 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11218318_1.fastq.gz	Fastqsanger.gz
	SRR11218318_2.fastq.gz	Fastqsanger.gz
	SRR11218319_1.fastq.gz	Fastqsanger.gz
	SRR11218319_2.fastq.gz	Fastqsanger.gz
	SRR11218320.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

RNA-Seq during tumor cell plasticity and Platr18 overexpression/silencing

Project description:The study aims: 1-to identify transcripts that are regulated during breast tumor cell plasticity induced by TGF-beta or by the silencing of PCBP1 expression and 2- to analyze the function of Platr18 lincRNA in breast cancer cells transcriptome reprogramming.

2021-10-20 | GSE146273 | GEO

The impact of inflammation-induced tumor plasticity during myeloid transformation

Project description:The impact of inflammation-induced tumor plasticity during myeloid transformation

| PRJNA757007 | ENA

The impact of inflammation-induced tumor plasticity during myeloid transformation [mononcytes]

Project description:The impact of inflammation-induced tumor plasticity during myeloid transformation [mononcytes]

| PRJNA832575 | ENA

protein turnover during homeostatic plasticity

Project description:Using quantitative proteomics we identified group of synaptic genes with decreased protein synthesis during homeostatic plasticity. To obtain further information about their mRNA levels/sequences (3’UTR) we performed polyA RNAseq. Using EISA analysis of Ribominus RNAseq dataset we could further differentiate between transcriptional respective post-transcriptional dependent alterations in mRNA levels. In addition Ribominus RNAseq from cell body and processes (dendrites, axons) RNA samples showed us local changes in mRNA levels during homeostatic plasticity. At the end, small RNAseq helped us to identify miRNAs that are increased during homeostatic plasticity and might regulate downregulated genes.

2017-04-05 | PXD004150 | Pride

Schwann cell plasticity regulates neuroblastic tumor cell differentiation

Project description:Schwann cell plasticity regulates neuroblastic tumor cell differentiation

| PRJNA615860 | ENA

LiX2019 - macrophage polarization and tumor cell plasticity

Project description:This model is based on: Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment. Abstract: Tumor microenvironments contain multiple cell types interacting among one another via different signaling pathways. Furthermore, both cancer cells and different immune cells can display phenotypic plasticity in response to these communicating signals, thereby leading to complex spatiotemporal patterns that can impact therapeutic response. Here, we investigate the crosstalk between cancer cells and macrophages in a tumor microenvironment through in silico (computational) co-culture models. In particular, we investigate how macrophages of different polarization (M1 vs. M2) can interact with epithelial-mesenchymal plasticity of cancer cells, and conversely, how cancer cells exhibiting different phenotypes (epithelial vs. mesenchymal) can influence the polarization of macrophages. Based on interactions documented in the literature, an interaction network of cancer cells and macrophages is constructed. The steady states of the network are then analyzed. Various interactions were removed or added into the constructed-network to test the functions of those interactions. Also, parameters in the mathematical models were varied to explore their effects on the steady states of the network. In general, the interactions between cancer cells and macrophages can give rise to multiple stable steady-states for a given set of parameters and each steady state is stable against perturbations. Importantly, we show that the system can often reach one type of stable steady states where cancer cells go extinct. Our results may help inform efficient therapeutic strategies.

2019-09-23 | MODEL1909230002 | BioModels

Chromatin plasticity contributes to neuronal selection during memory allocation

Project description:Memory allocation refers to the process by which neurons are recruited into the encoding ensemble to store learned information. This recruitment is regulated by neuronal selection based on differences in intrinsic excitability (IE) and the expression of the transcription factor CREB. However, whether other forms of plasticity influence memory allocation remains unknown. Here, we found that chromatin compaction and histone acetylation in the mouse lateral amygdala display a high degree of heterogeneity, a prerequisite for neuronal selection. Consequently, when we increased histone acetylation by overexpressing histone acetyl transferases (HATs), neurons with elevated histone acetylation were preferentially recruited into the encoding ensemble and memory retention was enhanced, while optogenetic silencing of the epigenetically altered neurons prevented memory expression. Mechanistically, using patch-clamp recordings and single-nucleus multi-ome sequencing, we observed that HAT overexpression increased IE and epitranscriptomic changes favoring synaptic plasticity. Lastly, by merging FRET-based epigenetic beacons with calcium indicators to simultaneously record histone acetylation and neuronal dynamics in real time, we found that epigenetic heterogeneity underlies IE in cell-autonomous manner. These results identify chromatin plasticity as a key factor catalyzing memory allocation.

2024-07-26 | GSE220696 | GEO

Natural Killer Cell Plasticity During IL-15-driven Homeostatic Proliferation

Project description:Here we performed single-cell RNA sequencing to address repertoire stability and subset plasticity during IL-15 driven homeostatic proliferation. Sorted NK cell subsets representing discrete stages of NK cell differentiation are compared with the corresponding subsets after proliferation and further sorted into two subsets depending on the rate of proliferation.

| EGAS00001003946 | EGA

Investigate how Sox9 overexpression influences ATII lineage plasticity by sc-multiome

Project description:Investigate how Sox9 overexpression influences ATII lineage plasticity by sc-multiome

| PRJNA1135134 | ENA

Epithelial cell plasticity drives endoderm formation during gastrulation

Project description:Epithelial cell plasticity drives endoderm formation during gastrulation

| PRJNA682168 | ENA