Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA321531
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Brain
SUBMITTER: Marek Rajman
LAB HEAD: Gerhard Schratt
PROVIDER: PXD004150 | Pride | 2017-04-05
REPOSITORIES: Pride
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The EMBO journal 20170509 12
Synaptic downscaling is a homeostatic mechanism that allows neurons to reduce firing rates during chronically elevated network activity. Although synaptic downscaling is important in neural circuit development and epilepsy, the underlying mechanisms are poorly described. We performed small RNA profiling in picrotoxin (PTX)-treated hippocampal neurons, a model of synaptic downscaling. Thereby, we identified eight microRNAs (miRNAs) that were increased in response to PTX, including miR-129-5p, who ...[more]