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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (RNA-Seq)

ABSTRACT: Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (RNA-Seq)

PROVIDER: PRJNA611580 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11272886.fastq.gz	Fastqsanger.gz
	SRR11272887.fastq.gz	Fastqsanger.gz
	SRR11272888.fastq.gz	Fastqsanger.gz
	SRR11272889.fastq.gz	Fastqsanger.gz
	SRR11272890.fastq.gz	Fastqsanger.gz

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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development

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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (ChIP-Seq)

Project description:Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (ChIP-Seq)

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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (RNA-Seq)

Project description:NF-κB-mediated signaling is maintained silent by the action of IκB proteins, whose canonical role is to sequester NF-κB in the cytoplasm. An alternative chromatin role for IκB members have been shown to affect stemness and cell differentiation but the involvement of NF-κB in this function has not been excluded. NFKI-1 and IKB-1 are IκB homologs in Caenorhabditis elegans, which lacks NF-κB nuclear effectors. nfki-1 and ikb-1 mutants present developmental defects that phenocopy mutations in Polycomb genes and demethylases as utx-1. suggesting a role for C. elegans IKB proteins in chromatin regulation, which is supported by various lines of evidence:(i) we detected NFKI-1 in the nucleus; (ii) NFKI-1 and IKB-1 bind to histones and Polycomb proteins, (iii) NFKI-1 and IKB-1 bind to chromatin in vivo, and (iv) mutations in nfki-1 and ikb-1 alter chromatin marks . Thus, ancestral IκB inhibitors may exert nuclear functions regulating of gene expression and development.

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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development (ChIP-Seq)

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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development.

Project description:Mammalian IκB proteins (IκBs) exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has been shown to affect stemness and cell differentiation. However, the involvement of NF-κB in this function has not been excluded. NFKI-1 and IKB-1 are IκB homologs in Caenorhabditis elegans, which lacks NF-κB nuclear effectors. We found that nfki-1 and ikb-1 mutants display developmental defects that phenocopy mutations in Polycomb and UTX-1 histone demethylase, suggesting a role for C. elegans IκBs in chromatin regulation. Further supporting this possibility (1) we detected NFKI-1 in the nucleus of cells; (2) NFKI-1 and IKB-1 bind to histones and Polycomb proteins, (3) and associate with chromatin in vivo, and (4) mutations in nfki-1 and ikb-1 alter chromatin marks. Based on these results, we propose that ancestral IκB inhibitors modulate Polycomb activity at specific gene subsets with an impact on development.

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