Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA611626 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR11278102.fastq.gz | Fastqsanger.gz | |||
| SRR11278103.fastq.gz | Fastqsanger.gz | |||
| SRR11278104.fastq.gz | Fastqsanger.gz | |||
| SRR11278105.fastq.gz | Fastqsanger.gz | |||
| SRR11278106.fastq.gz | Fastqsanger.gz |
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Project description:We analyzed the genome wide localization of H3K4me3, H3K27me3 and the NUP98-PHF23 (with V5 tag) fusion protein which binds H3K4me3 via its PHD finger, using ChIP-seq. Results correlated with gene expression profiles. NUP98-PHF23 bound only 1.6% of H3K4me3 marks including Hoxa/b + Meis1. Assess H3K4me3 and H3K27me3 histone marks, and correlate these marks with chromatin binding of the NP23 fusion protein using lymphoblast and myeloblast cell lines derived from NP23 leukemias.
2014-03-06 | E-GEOD-54786 | biostudies-arrayexpress