Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus musculus breed:C57BL/6

ABSTRACT: Single-cell and spatial transcriptomics from healthy and influenza-infected mice

PROVIDER: PRJNA612345 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11430600_1.fastq.gz	Fastqsanger.gz
	SRR11430600_2.fastq.gz	Fastqsanger.gz
	SRR11430601_1.fastq.gz	Fastqsanger.gz
	SRR11430601_2.fastq.gz	Fastqsanger.gz
	SRR11430602_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Mus musculus breed:C57BL/6J

Project description:Brain transcriptomics of genome-edited mice with humanized Vmat1 genotype

| PRJNA660500 | ENA

The Tabulae Paralytica: Multimodal single-cell and spatial atlases of spinal cord injury

Project description:This submission is a dataset of two modalities, single-nucleus transcriptomics and single-nuclei spatial transcriptomics in the spinal cords of mice. The single-nuclei transcriptomics data is harvested and profiled using 10x Genomics Chromium Single Cell Kit Version. The single-nuclei spatial transcriptomics data is harvested and profiled using Visium Spatial Gene Expression.

2024-01-30 | GSE234774 | GEO

Analysis of gene expression in the lung of influenza virus infected C57BL/6 mice

Project description:We employ cDNA microarry(Agilent Mouse lncRNA (4*180K,Design ID:049801) ) to detect the differential expression of mRNAs and lncRNAs in the lung of mice infected with or without A/WSN/33 influenza virus. Microarry analysis revealed that 2092 mRNAs and 1640 lncRNAs differentially expressed in the lung of IAV infected mice compared to control,including 1399 mRNAs and 1052 lncRNAs upregulated, 693 mRNAs and 588 lncRNAs downregulatded. Our finding indicates that thousands of genes are involved in and may play critical roles in the influenza virus-host interactions.

2019-09-11 | GSE80011 | GEO

Single-Cell and Spatial Transcriptomics Analysis of Human Adrenal Aging (spatial transcriptomics)

Project description:These data were used in the spatial transcriptomics analysis of the article titled \\"Single-Cell and Spatial Transcriptomics Analysis of Human Adrenal Aging\\".

2024-04-22 | E-MTAB-13991 | biostudies-arrayexpress

Spatial transcriptomics of brains from tumor-bearing C57BL/6 mice

Project description:GL261-derived glioblastoma stem cells (GSCs) form aggressive tumors when implanted into the brains of C57BL/6 mice. We used spatial transcriptomics to analyze brain sections of tumor-bearing C57BL/6 mice at 28 days post-implantation

2024-03-28 | GSE245263 | GEO

Mus musculus

Project description:RNA-seq influenza infected B6 & D2 mice

| PRJNA275751 | ENA

Transcriptional response in influenza-infected lungs from C57BL/6 wt, 129S7 wt and IFNAR-/- (129) mice

Project description:We used microarrays to analyse the global program of gene expression in response to Influenza A (X31) infection in lungs from C57BL/6 wt, 129S7 wt and IFNAR-/- (129) mice. Mock- or 5 day influenza A (X31)-infected total lungs from mice with the indicated genotypes were collected and processed for expression profiling.

2014-04-30 | E-GEOD-55403 | biostudies-arrayexpress

Time series of flu-infected lungs of DBA/2J and C57BL/6J mice

Project description:DBA/2J (D2) and C57BL/6J mice (B6) were infected intra-nasally with 2x10^3 FFU of influenza A H1N1 (PR8) virus. Lungs were collected from mock-infected controls or at day 1,2,3,4 post infection. Expression data were obtained from three independent experiments. We infected a highly susceptible mouse strain (D2) and a resistant strain (B6) with PR8 and performed a genome-wide expression analysis. We found genes expressed in lung epithelium that were specifically down-regulated in D2 mice, whereas a cluster of genes on chromosome 3 was only down-regulated in B6. In both mouse strains, chemokines, cytokines and interferon-response genes were up-regulated, indicating that the main innate immune defense pathways were activated. However, many immune response genes were up-regulated in D2 much stronger than in B6, and several immune response genes were exclusively regulated in D2. Thus, susceptible D2 mice showed a hyper-inflammatory response. This response is similar to infections with highly pathogenic influenza virus and may serve as a paradigm for a hyper-inflammatory host response to influenza A virus.

2011-12-01 | E-MTAB-835 | biostudies-arrayexpress

Interferon Gamma signaling triggers dysplastic alveolar remodeling during respiratory viral infection

Project description:A single-cell transcriptional analysis was performed on lung epithelial cells isolated from influenza PR8 infected mice at 14 days post injury. The goal is to investigate the potential signaling pathway that regulates dysplastic KRT5 cells expansion. The left lung lobe from influenza infected mice were dissociated to single cells and subjected to fluorescence activated cell sorting (FACS) to select all Epcam+ cells. We found that the regulation of actin cytoskeleton, focal adhesion, Hippo signaling pathway are highly activated in dysplastic KRT5+ cells, suggesting that these signaling pathway may play a role in the expansion of dysplastic KRT5 cells in influenza infected lungs.

2024-07-31 | GSE234082 | GEO

Mus musculus strain:C57Bl/6

Project description:Microbiome changes in mice after influenza viral infection

| PRJNA393321 | ENA