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Dnmt1 deletion in Hmx3-positive POA-derived interneurons

ABSTRACT: Dnmt1 deletion in Hmx3-positive POA-derived interneurons

PROVIDER: PRJNA612519 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11305718.fastq.gz	Fastqsanger.gz
	SRR11305719.fastq.gz	Fastqsanger.gz
	SRR11305720.fastq.gz	Fastqsanger.gz
	SRR11305721.fastq.gz	Fastqsanger.gz
	SRR11305722.fastq.gz	Fastqsanger.gz

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Dnmt1 deletion in Hmx3-positive POA-derived interneurons [MeDIP-seq]

Project description:The proliferative niches in the subpallium generate a rich cellular variety fated for diverse telencephalic regions. The embryonic preoptic area (POA) represents one of these domains giving rise to the pool of cortical GABAergic interneurons and glial cells, in addition to striatal and residual POA cells. The migration from sites of origin within the subpallium to the distant targets like the cerebral cortex, accomplished by the adoption and maintenance of a particular migratory morphology, is a critical step during interneuron development, which seems to be regulated partially via DNA methylation-dependent gene expression. To identify genes that are altered by DNA methylation mediated by DNMT1 in POA-derived Hmx3-positive interneurons, we used an Hmx3-Cre/tdTomato/Dnmt1loxP mouse model and FAC-sorted the basal telencephalon at E16. RNA and MeDIP sequencing were performed. MeDIP data are assigned here.

2021-03-09 | GSE146967 | GEO

Dnmt1 deletion in Hmx3-positive POA-derived interneurons [RNA-seq]

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Dnmt1 deletion in Hmx3-positive POA-derived interneurons [RNA-seq]

Project description:Dnmt1 deletion in Hmx3-positive POA-derived interneurons [RNA-seq]

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Dnmt1 deletion in Hmx3-positive POA-derived interneurons [MeDIP-seq]

Project description:Dnmt1 deletion in Hmx3-positive POA-derived interneurons [MeDIP-seq]

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Dnmt1 deletion in Hmx3-positive POA-derived interneurons

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-09 | GSE146968 | GEO

Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice

Project description:Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice

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Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice [RNA-seq]

Project description:Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice [RNA-seq]

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Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice [meDIP-seq]

Project description:Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice [meDIP-seq]

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Disruption of KCC2 in parvalbumin-positive interneurons causes fatal epilepsy in mice

Project description:Since many years, we are interested in the regulation of the intraneuronal chloride concentration. We were the first group reporting a full knockout of the KCl-co-transporter KCC2, which dies immediately after birth due to respiratory failure. Notably, KCC2 loss-of-function mutations are associated with inherited febrile seizures, severe genetic generalized epilepsy and epilepsy of infancy with migrating focal seizures. Here, we used our floxed line to study the consequences of the disruption of KCC2 within parvalbumin-positive interneurons in mice. Remarkably, this leads to the disinhibition of PV-positive interneurons as evidenced by a decrease of E-S-Coupling and an increase in the sIPSC frequency. Nevertheless, these mice develop fatal epilepsy with progressive loss of parvalbumin-positive interneurons thus increasing network excitability.

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Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice

Project description:The emerging role of epigenetic mechanisms like DNA methylation executed by DNA methyltransferases (DNMTs) in synaptic function irrevocably raises the question for the targeted subcellular processes and mechanisms. We here sequenced FAC-sorted PVergic interneurons of 6 month and 18month old PV-Cre/tdTomato/Dnmt1loxp wildtype and knockout mice and performed RNA-Seq and MeDIP-Seq.

2020-07-06 | GSE145026 | GEO

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