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Investigating the role of IL-2 in shaping the epigenome in T cells [ChIP-seq]

ABSTRACT: Investigating the role of IL-2 in shaping the epigenome in T cells [ChIP-seq]

PROVIDER: PRJNA613696 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11359457.fastq.gz	Fastqsanger.gz
	SRR11359458.fastq.gz	Fastqsanger.gz
	SRR11359459.fastq.gz	Fastqsanger.gz
	SRR11359460.fastq.gz	Fastqsanger.gz
	SRR12474738.fastq.gz	Fastqsanger.gz

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Investigating the role of IL-2 in shaping the epigenome in T cells [ChIP-seq]

Project description:During T cell activation hundreds of genes are primed for efficient activation. Here we show that IL-2 signaling is required to maintain open chromatin at gene regulatory elements which are associated with alternate pathways of T cell differetiation.IL-2 actiavtes binding of AP-1 and STAT5 at sites that can subsequently bind other STAT and lineage dietermining proteins, depending on what other factors exist in their enviroment.

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