Project description:In order to gain insight into the molecular mechanism of PROKR1, we investigated transcriptomic response in PROKR1 overexpressed HEK293 T cells following Pk2 stimulation We identified 578 differentially expressed genes (DEGs) fold change cutoff = 2 in activated HEK293 T overexpressed HEK293 T cells by Pk2, including 269 up-regulated and 309 down-regulated genes.
Project description:We present RNA-Seq data obtained from HEK293T cells and HEK293T cells with ALKBH5 and FTO demethylases double knockout (HEK293TΔALKBH5ΔFTO), showing m6A-dependent transcriptome alterations.
Project description:The primary objective of this prospective observational study is to characterize the gut and oral microbiome as well as the whole blood transcriptome in gastrointestinal cancer patients and correlate these findings with cancer type, treatment efficacy and toxicity. Participants will be recruited from existing clinical sites only, no additional clinical sites are needed.
Project description:cGAS-STING expression in HEK293T cells could up regulate a series of genes. Above them, Vpx significantly suppressed the NF-κB activated genes but had only a slight influence on the IRF3-activated genes. Diverse HIV-2 and SIV Vpx proteins showed an ability to inhibit DNA sensing-activated innate immune responses, suggesting an evolutionarily conserved function for Vpx.