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PAgo-induced DNA interference protects bacteria from invader DNA [gDNA]

ABSTRACT: pAgo-induced DNA interference protects bacteria from invader DNA [gDNA]

PROVIDER: PRJNA625095 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11541039.fastq.gz	Fastqsanger.gz
	SRR11541040.fastq.gz	Fastqsanger.gz
	SRR11541041.fastq.gz	Fastqsanger.gz
	SRR11541042.fastq.gz	Fastqsanger.gz
	SRR11541043.fastq.gz	Fastqsanger.gz

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pAgo-induced DNA interference protects bacteria from invader DNA

Project description:pAgo-induced DNA interference protects bacteria from invader DNA

| PRJNA625099 | ENA

pAgo-induced DNA interference protects bacteria from invader DNA [smDNA]

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pAgo-induced DNA interference protects bacteria from invader DNA [gDNA]

Project description:Members of the conserved Argonaute protein family use small RNA guides to find their mRNA targets to regulate gene expression and suppress mobile genetic elements in eukaryotes. Argonautes are also present in many bacterial and archaeal species. Unlike eukaryotic proteins, several studied prokaryotic Argonautes use small DNA guides to cleave DNA, a process dubbed DNA interference. However, the natural functions and targets of DNA interference are poorly understood and the mechanisms of DNA guide generation and target discrimination remain unknown. Here, we studied the in vivo activities of a bacterial Argonaute nuclease CbAgo and demonstrated that it induces cleavage of multicopy genetic elements, including plasmids, transposons and repetitive chromosomal loci. Generation of small DNA guides employed by CbAgo requires cooperation between its intrinsic endonuclease activity and the cellular double-strand break repair machinery. The mechanism of guide generation ensures that small DNA guides are enriched in sequences that target foreign DNA and endows CbAgo with capacity to eliminate plasmids and fight phage infection. Similar principles may underlie the specificity of self-nonself discrimination by diverse defense systems in prokaryotes.

2020-07-30 | GSE148594 | GEO

pAgo-induced DNA interference protects bacteria from invader DNA [smDNA]

2020-07-30 | GSE148595 | GEO

pAgo-induced DNA interference protects bacteria from invader DNA

Project description:This SuperSeries is composed of the SubSeries listed below.

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DNA bisulfite sequencing of Invader 4 LTRs in Drosophila

Project description:It has been claimed previously that loss of (cytosine-5) DNA methylation in Dnmt2 mutant embryos affected the establishment of silent chromatin at Invader4 LTRs (Phalke et al., 2009). The inability of Dnmt2 mutants to control TE expression after heat shock (GSE40432) raised the possibility that DNA methylation could be required for control of Invader 4 during the heat shock response. We used DNA bisulfite sequencing at Inv4 LTRs that were previously suggested to be methylated (Phalke et al., 2009).

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Genotyping of human family trios using placental cDNA, placental genomic DNA (gDNA) and gDNA from both parents to find new imprinted genes

Project description:Twenty-three family trios of placental cDNA, placental genomic DNA (gDNA) and gDNA from both parents were tested using Illumina SNP arrays to find new imprinted genes to ascertain the extent of allele specific expression in this tissue.

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Environmental soil gDNA extraction

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