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Microarray profiling analysis of microRNAs expression in glioblastoma cells

ABSTRACT: Microarray profiling analysis of microRNAs expression in glioblastoma cells

PROVIDER: PRJNA625711 | ENA |

REPOSITORIES: ENA

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Microarray profiling analysis of microRNAs expression in glioblastoma cells

Project description:Although growing evidence has revealed that ZEB2 was correlated with grades and outcome of glioma positively, the mechanisms underlying ZEB2/miRNAs-mediated gliomas development remain largely unknown. Here the authors revealed that ZEB2 raised in glioblastoma samples compared to the lower-grade gliomas. Besides, miR-637 increased to the most extent per the miRNA array analysis of cells with- or without ZEB2. ZEB2 captured the promoter of miR-637 directly and suppressed miR-637 transcription. In the absence of ZEB2, overexpressed miR-637 targeted WNT7A and repressed the WNT/β-Catenin signaling pathways subsequently, which inhibited the expression of Cyclin D1 and Vimentin. Importantly, the combination of β-Catenin-specific inhibitor LGK974 and temozolomide hampered cell proliferation synergistically in cells expressing miR-637. In line with the expectation, the inhibition of miR-637 counteracted sh-ZEB2-caused tumor regression in U251 xenograft models. The current study evaluated a novel mechanism that the association of ZEB2/miR-637/WNT7A contributed to regulate glioblastoma cell proliferation and migration in a β-Catenin-dependent manner. The results may provide new rationales to optimize the trial designs, which try to select the ideal glioblastoma patients to receive β-Catenin-targeted therapy and chemotherapy.

2020-04-17 | GSE148779 | GEO

Microarray profiling analysis of microRNAs expression in Hypertrophic scar

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Microarray profiling analysis of microRNAs expression in diabetes samples

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MicroRNA profiling of human glioblastoma cell lines and tissue samples identifies microRNAs whose expression is altered in glioblastoma multiforme

Project description:MicroRNAs are short non-coding RNA molecules playing regulatory roles in animals and plants by repressing translation or cleaving RNA transcripts. The specific modulation of several microRNAs has been recently associated to some forms of human cancer, suggesting that these short molecules can represent a new class of genes involved in oncogenesis. In our study, we examined by microarray the global expression levels of 245 microRNAs in glioblastoma multiforme (GBM), the most frequent and malignant of primary brain tumors. The analysis of both glioblastoma tissues and glioblastoma cell lines allowed us to identify a group of microRNAs whose expression is significantly altered in this tumor. The most interesting results came from miR-221, strongly upregulated in glioblastoma and a set of brain-enriched miRNAs, miR-128, miR-181a, miR-181b, miR-181c, which are down-regulated in glioblastoma.

2005-09-23 | E-TABM-37 | biostudies-arrayexpress

MicroRNAs and mRNAs differentially expressed in 5 glioblastoma spheroid cultures upon ATRA treatment

Project description:Microarray-based gene expression analysis identified microRNAs and mRNAs differentially expressed in 5 glioblastoma spheroid cultures upon ATRA treatment.

2010-07-20 | GSE17227 | GEO

MicroRNAs and mRNAs differentially expressed in 5 glioblastoma spheroid cultures upon ATRA treatment

Project description:Microarray-based gene expression analysis identified microRNAs and mRNAs differentially expressed in 5 glioblastoma spheroid cultures upon ATRA treatment. In this study, a set of 5 glioblastoma spheroid cultures was used to acquire microRNA expression profiles, leading to the identification of differentially expressed microRNAs between untreated and ATRA-treated cultures. In this study, a set of 5 glioblastoma spheroid cultures was used to acquire expression profiles of a total of 16,651 transcripts, leading to the identification of differentially expressed genes between untreated and ATRA-treated cultures by Significance Analysis of Microarray data.

2010-07-20 | E-GEOD-17227 | biostudies-arrayexpress

Microarray analysis of microRNAs expression in A549 cells during influenza A virus infection

Project description:Microarray analysis of microRNAs expression in A549 cells during influenza A virus infection

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Microarray profiling analysis of microRNAs expression in NFATc3-overexpressed human monocyte-derived macrophages (HMDMs)

Project description:Microarray profiling analysis of microRNAs expression in NFATc3-overexpressed human monocyte-derived macrophages (HMDMs)

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Cell-Free Plasma MicroRNAs that Identify Patients with Glioblastoma

Project description:This retrospective multicenter pilot study aims to determine potential cell-free microRNAs (cfmiRs) that identify patients with primary GBM (pGBM) tumors and to monitor Glioblastoma (GBM) recurrence.

2023-05-26 | GSE184472 | GEO

microRNA expression profiling in human brain glioblastoma

Project description:The expression profiling of a total of 2085 microRNAs in 5 glioblastoma and 5 normal brain cases, which had been consecutively operated on within a defined short period of time

2018-08-31 | GSE103228 | GEO

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