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Expression data from adult wild-type and transgenic zebrafish revealed Oligo-Fucoidan Prevents Radiation induced fibrosis and secondary tumors in zebrafish

ABSTRACT: Expression data from adult wild-type and transgenic zebrafish revealed Oligo-Fucoidan Prevents Radiation induced fibrosis and secondary tumors in zebrafish

PROVIDER: PRJNA625883 | ENA |

REPOSITORIES: ENA

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Expression data from adult wild-type and transgenic zebrafish revealed Oligo-Fucoidan Prevents Radiation induced fibrosis and secondary tumors in zebrafish

Project description:Radiotherapy (RT) often causes unwanted side effects such as radiation-induced fibrosis (RIF) and second malignancies (SM). Fucoidan, a sulfated polysaccharide extracted from brown seaweed, has many biological effects including anti-inflammation and anti-tumor. In the present study, we investigated the radioprotective effect of Oligo-Fucoidan (OF) using zebrafish animal model. Using an oligo-fucoidan oral gavage in wild-type and adult transgenic zebrafish, we then used microarrays to detail the global programme of gene expression after fucoidan treatment and identified distinct classes of up- and down-regulated genes during this process.

2020-04-18 | GSE148811 | GEO

Expression data from adult transgenic zebrafish

Project description:Hepatocellular carcinoma is the fourth leading cause of cancer-related deaths worldwide. Many carcinogens induce inflammation and cirrhosis, and eventually develop into liver cancer. Fucoidan is sulfated polysaccharide that is mainly found in brown seaweeds. In this study, we investigated the effects and mechanisms of low molecular weight fucoidan (i.e. oligo-fucoidan) preventing hepatocarcinogenesis using HBx,Src, and HBx,Src,p53-/+ transgenic zebrafish liver cancer model. Using an oligo-fucoidan oral gavage in adult transgenic zebrafish, we then used microarrays to detail the global programme of gene expression after fucoidan treatment and identified distinct classes of up- and down-regulated genes during this process.

2020-04-12 | GSE148501 | GEO

Expression data from adult zebrafish

Project description:Oligo-fucoidan (OF), a sulfated polysaccharide extracted from brown seaweed, exhibits anti-inflammation and antitumor effects, however, knowledge concerning the detailed mechanism of oligo-fucoidan on liver cells is obscure. In this study, we investigate the effect of oligo-fucoidan in normal hepatocytes using transcriptomic analysis. Using an oligo-fucoidan oral gavage in adult wild-type zebrafish, we then used microarrays to detail the global programme of gene expression after fucoidan treatment and identified distinct classes of up- and down-regulated genes during this process.

2020-04-09 | GSE148324 | GEO

Gene expression profiles of zebrafish larvae exposed to secondary effluent of a wastewater treatment plant in Tucson, Arizona, USA

Project description:To investigate gene expression changes in fish by the secondary effluent (directly released to environment) of a waterwater treatment plant in Tucson, Arizona, zebrafish larvae with 5-day exposure to the original (1x) or half (0.5x) concentration of the effluent were analyzed using Agilent G2519F-026437 Zebrafish Oligo Microarray.

2018-01-01 | GSE93532 | GEO

Bulk RNA-seq data to assess an improved zebrafish transcriptome annotation

Project description:oligo-dT and random primed RNA-seq libraries were used to test an improved annotation of the zebrafish transcriptome

2020-07-28 | GSE152759 | GEO

Expression data from adult transgenic zebrafish

Project description:Expression data from adult transgenic zebrafish

| PRJNA624764 | ENA

Identification of Hoxb1b regulated genes in zebrafish embryos

Project description:Microarrays containing the Compgen/Sigma-Genosys XEBLIB96 oligo set (which represents about 12,500 unique genes) was used to identify 100 genes up-regulated more than 2-fold by hoxb1b in zebrafish embryos

2011-07-15 | GSE30632 | GEO

Sodium valproate is protective in a transgenic zebrafish model of Machado Joseph disease

Project description:The neurodegenerative disease Machado Joseph disease (MJD, also known as spinocerebellar ataxia-3) is a fatal disease that impairs control and co-ordination of movement. MJD is caused by expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, encoding a long polyglutamine (polyQ) region within the ataxin-3 protein. As transcription regulation is one of the functions of the ataxin-3 protein, weWe aimed to examine whether zebrafish expressing polyQ expanded ataxin-3 had altered levels of histone acetylation, and to establish test whether treatment with the histone deacetylase (HDAC) inhibitor sodium valproate was protective for the the first transgenic zebrafish.

2021-08-23 | PXD009612 | Pride

KM109_Human oligo batch II

Project description:Timecourse experiment hybridized to human oligo array part II. Healthy human primary myoblasts (KM109). Keywords: time-course

2004-02-12 | GSE909 | GEO

Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG)

Project description:This is a phase 2 pragmatic study that evaluates the clinical benefit of continuing systemic therapy with the addition of locally ablative therapies for oligo-progressive solid tumors as the primary objective. The primary outcome measure is the time to treatment failure (defined as time to change in systemic failure or permanent discontinuation of therapy) following locally ablative therapy.

| 114756 | ecrin-mdr-crc

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